التحقيق في النشاط العدواني والحيوي العصبي لاستخراج لحاء Myristica malabarica على ضعف الإدراك الناجم عن STZ في الحيوانات التجريبية
DOI:
https://doi.org/10.35516/jjps.v16i2.1318الكلمات المفتاحية:
Myristica malabarica، الحماية العصبية، تراجع الإدراكالملخص
تهدف الدراسة الحالية إلى تقييم مستخلصات Myristica malabarica Bark ( MM ) في نموذج الفئران المعرفي الناجم عن مرض السكري لنشاطه العدواني والحماية العصبية. تم تقييم نشاط تعزيز الذاكرة بواسطة اختبار المتاهة Y واختبار متاهة الماء موريس، على التوالي. تم تقييم التأثيرات العصبية الواقية لمستخلصات لحاء MM عن طريق قياس أستيل كولين استريز، بيروكسيد الدهون، ديسموتاز سوبروكسيدSOD ) )، إجمالي أكسيد النيتريكNO ), ) مستويات الكاتالاز CAT ) ) والغلوتاثيون GSH ) ) في دماغ الفئران المصابة بالسكري. لوحظ أن مستخلص كحول الميثيل لحاء Myristica malabarica ( MMMA ) ( 100 و 200 مجم / كجم ) يؤثر على تحسن كبير في التغيير التلقائي
P < 0.01, P < 0.001 ) ) ووقت الاستجابة للنقلP < 0.01 P < 0.001 ) ) في تجارب الاحتفاظ على متاهة Y واختبار متاهة الماء Morris على التوالي. ومع ذلك، انخفاض كبير في نشاط أستيل كولين استريز(P < 0.001 )، بيروكسيد الدهون ( P < 0.001 )، إجمالي NO ( P < 0.001 ) وزيادة كبيرة في SOD, لوحظت مستويات CAT و GSH ( P < 0.001 ) في الحيوانات المعالجة بـ MMMA ( 200 مجم / كجم ) المتعلقة بمجموعة مكافحة مرضى السكري. تشير النتائج الحالية إلى أن مقتطفات Myristica malabarica كانت تدافع عن الانخفاض المعرفي في حالة مرض السكري والذي يتطلب بعض الدراسات الإضافية لتوضيح طريقة عملها.
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