عدم وجود ارتباط بين تعدد الأشكال الجيني الكاتليز ( 262السيتوزين>الثايمين) مع التعرض للبهاق بين الأردنيين: دراسة حالة مراقبة
DOI:
https://doi.org/10.35516/jjps.v16i2.438الكلمات المفتاحية:
تعدد الأشكال الجيني، الكاتليز في الدم، الجين Cat 262- سيتوسين، ثيامين، الاردنيونالملخص
يتم جلب البهاق عن طريق فقدان الخلايا الصباغية الوظيفية ويظهر على شكل بقع بيضاء قد تغطي جلد الجسم كله. هناك خلفية وراثية في التسبب في البهاق. تعدد الأشكال في أجزاء مختلفة من الجينات الكاتلاز قد تؤثر على نشاط المرض وتؤدي إلى تقليل وظيفة الكاتليز، وبالتالي، تراكم بيروكسيد الهيدروجين، واحدة من العوامل المؤكسدة التي تضر الخلايا الصباغية، واحدة من العوامل المؤكسدة التي تضر الخلايا الصباغية. قمنا بتقييم تعدد الأشكال الجيني CAT 262 من مرضى تعدد الاشكال الوراثي البهاق باستخدام تقنية تفاعل البلمرة المتسلسل PCR) ) مع واحد على الأقل سي ونموذج تي واحد على الأقل. وشملت الدراسة 48 مريض البهاق و51 عينة ضابطه. كان التاريخ العائلي للبهاق موجودا في 27.1 ٪ من المرضى وتم تشخيص أمراض المناعة الذاتية في 16.0 ٪ من المرضى. أفاد حوالي ثلاثة أرباع مرضى البهاق (75.0٪) أن التوتر النفسي كان العامل الرئيسي المسبب لمرضهم. كان النمط الجيني CC السائد (56.2% لمرضى البهاق و 62.7% للظابطه) مع عدم وجود فرق كبير بين مجموعة الدراسة P=0.7). ) كان نشاط الكاتليز في الدم متقارب بين أطراف الدراسة (159.1± MU 21.6 وحدة/لتر في مرضى البهاق و151.3 ± 25.4 وحدة/لتر في العينه الضابطه P=0.15). ) نستنتج أنه لا يرتبط تعدد الأشكال الجيني في CAT262 ولا نشاط الكاتليز في الدم بالبهاق.
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