Phytosomes: A Cutting-Edge Platform for Phytochemicals Delivery by Enhancing Bioavailability
DOI:
https://doi.org/10.35516/jjps.v17i4.2488Keywords:
Phytosomes, phospholipid complex, bioavailability, phytoconstituents, nanocarrierAbstract
The word "Phyto" signifies plant, while "some" is for cell. This innovative patented technology involves combining plant extracts or hydrophilic phytoconstituents with phospholipids to create lipid-suitable molecular complexes, resulting in not only enhanced absorption but also bioavailability. Extensive research has been conducted by various scientists to explore the transdermal way as an excellent method for delivering phytoconstituents. Phyto products or Phyto extracts are gaining significant consideration as dietary complements in managing inflammation, toxicity, cancer, weight loss, and various chronic degenerative conditions. Nevertheless, continuous advancements and studies are being conducted in this fieldthese products frequently encounter issues with stability and bioavailability. Once extracted, plant products become susceptible to instability and may not be suitable for passage through a biological membrane. This technique enhances the hydrophilicity of highly lipophilic drugs, manufacturing them convenient for drug delivery, and adequately enhance the lipophilicity of Phyto constituents to facilitate permeation through the bio- membrane. The use of Phytosomes for beautifying purposes has already been scientifically established. Additionally, this review offers a relative analysis of liposomes and Phytosomes, highlighting current developments in Phytosomes technology, mostly in transdermal drug delivery. Incorporation of polyphenol compounds into a self-assembled phospholipid-based delivery system, known as a Phytosomes, can significantly improve their poor oral bioavailability.
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