Antioxidant and Cytotoxic Activity of Lentinus fasciatus


  • Arghya Naskar Department of Botany, University of Calcutta, India
  • Adhiraj Dasgupta Department of Botany, University of Calcutta, India
  • Krishnendu Acharya Department of Botany, University of Calcutta, India



Antioxidant property, cytotoxicity, radicals, methanolic extract, mushroom


The genus Lentinus is one of the most studied and medicinally significant groups among mushrooms. Lentinus fasciatus is a considerably understudied species and a methanolic formulation was evaluated for its medicinal potential. Phytochemical analysis unveiled the presence of a high amount of phenolic substances in the methanolic extract of the basidiocarps of L. fasciatus. The extracted fraction showed notable scavenging properties in in-vitro antioxidant property estimation assays. In the ABTS and DPPH assay, respectively, the EC50 values were 332.12 and 180.78 μg/mL. The mushroom extract was also screened for cytotoxic activity against the human breast adenocarcinoma cells (MCF-7). The biocidal activity against cancer cells is further proven by the low LD50 value of 246 g/mL in the WST-1 experiment. The background mechanism behind the cytotoxicity was predicted to be mediated by the apoptotic pathways.

Author Biographies

Arghya Naskar, Department of Botany, University of Calcutta, India

Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, India.

Adhiraj Dasgupta, Department of Botany, University of Calcutta, India

Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, India.

Krishnendu Acharya, Department of Botany, University of Calcutta, India

Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, India.


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How to Cite

Naskar, A. ., Dasgupta, A. ., & Acharya, K. . (2023). Antioxidant and Cytotoxic Activity of Lentinus fasciatus. Jordan Journal of Pharmaceutical Sciences, 16(1), 72–81.