Evaluation of Basella alba L. Mucilage as a Suspending Agent in Metronidazole Suspension
DOI:
https://doi.org/10.35516/jjps.v15i3.418Keywords:
Basella alba, Suspensions, Suspending agents, MetronidazoleAbstract
In the quest for natural biodegradable, non-toxic polymers for use as excipients in pharmaceutical formulations, mucilage of Basella alba L (BAM) stem was isolated and evaluated as a suspending agent in metronidazole suspensions at different concentrations (0.5% - 2% w/v) in comparison to tragacanth (TCG) and gelatin gums (GLT). The micromeritic properties of the mucilage powder were determined and the metronidazole suspension was characterized using flow rate, redispersion number, sedimentation volume, viscosity and pH. The degree of flocculation was also determined. BAM powder has good flow property with minimal swelling. The order of flow rate of metronidazole suspension was BAM=TCG>GLT while sedimentation volume ranking was TCG>BAM>GLT. There was no significant difference (p>0.05) in the redispersion number of BAM and TCG formulations. The viscosities of formulations containing BAM and TCG at concentrations of 0.5%-1.0% w/v were the same. The pH of the suspensions ranged from 5 to 8. The degree of flocculation was in the order GLT>BAM>TCG. From our findings, BAM can be used as an alternative suspending agent in suspension formulation.
References
Malviya R., Srivastava P., Kumar U., Bhargava C.S and Sharma, P. K. Formulation and comparison of suspending properties of different natural polymers using paracetamol suspension. International Journal of Drug Development & Research. 2010; 2(4):886-891
Kusuma R. and Rao S.S. Appilication of Ipomoea Batata starch mucilage as a suspending agent in oseltamiviar suspension. International Journal of current Pharmaceutical Research. 2015; 7 (4): 58-62
Kulkarni V.S. and Shaw C. In: Essential Chemistry for Formulators of Semisolid and Liquid Dosages. Elsevier Amsterdam, 2015, Ist edition, chapter 5, pp 43-69.
Haile T.G., Sibhat G.G., Tadese E, Tesfay D. and Molla F. (2020). Evaluation of Grewia ferruginea Hochst ex A. Rich Mucilage as Suspending Agent in Metronidazole Benzoate Suspension. Biomed Research International. Available https://www. hindawi.com/ journals/ bmri/2020/ 7612126/
Saroj V., Rao P.S., Rao S.K. and Krunal S. Pharmacognostical study of Basella alba stem. International Journal of Research in Pharmaceutical and Biological Sciences. 2012; 3: 1093-1094.
Palada M.C. and Crossman S.M.A. Evaluation of tropical leaf vegetables in the Virgin Islands. Perspectives on new crops and new uses; ASHS press: Alexandria, VA. 1999, p. 388-393.
Roy S.K., Gangopadhyay G. and Mukherjee K.K. Is stem twining form of Basella alba L. a naturally occurring variant. Current Science. 2010; 98: 1370-1375.
Bamidele O., Akinnuga A.M., Olorunfemi J.O., Odetolo O.A., Oparaji C.K. and Ezelgbo N. Effects of aqueous extract of Basella alba leaves on haematological and biochemical parameters in Albino rats. African Journal of Biotechnology. 2010; 9: 6952-6955.
Izonfuo W.A.L., Fekarurhobo G.K., Obomanu F.G. and Daworiye L.T. Acid base indicator properties of dyes from local plants I: dyes from Basella alba (Indian spinach) and Hibiscus sabdariffa. Journal of Applied Science and Environment Management. 2006; 10: 5-8.
Mohammed H.K.P., Abraham A., Saraswathi R., Mohanta G.P. and Nayar C. Formulation and evaluation of herbal gel of Basella alba for wound healing activity. Journal of Pharmaceutical Sciences and Research. 2012; 4: 1642-1648.
Verma H.N. and Varsha B.V.K. Endogenous virus inhibitors from plants, their physical and biological properties. Antiviral proteins in higher plants; Chessin M., DeBorde D. and Zipf. A. (Ed): CRC Press; USA.1995; pp1-21.
Deshmukh S.A. and Gaikwad D.K. A review of the taxonomy, ethnobotany, phytochemistry and pharmacology of Basella alba (Basellaceae). Journal of Applied Pharmaceutical Science. 2014; 4 (1): 153-165
Kumar V., Bhat Z.A. and Kumar D. 2011(a). Evaluation of Basella alba leaves mucilage as an innovative suspending agent. Abstract book of National Seminar on Recent Advances in Oral Controlled Drug Delievery System organized by: Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of pharmacy, Bela, Ropar. Paper code F10, pp.3.
Ramu G., Krishna-Mohan G., Jayaveera KN. Preliminary investigation of patchaippasali mucilage (Basella alba) as tablet binder. International Journal of Green Pharmacy. 2012; 5: 24-27.
Bhat V., Nayak R. and Praveena M.B. Isolation and evaluation of disintegrating properties of Basella alba Linn. Leaf mucilage in tablet formulations. Journal of Biomedical and Pharmaceutical Research. 2015; 4 (2): 29-42
Chatchawal C., Nualkaew N., Preeprame S., Porasuphatana S.and Priprame A. Physical and biological properties of mucilage from Basella alba L. stem and its gel formulations. International Journal of plant Sciences. 2010; 6: 104-112
Olayemi O.J., Ekunboyejo A., Bamiro O.A. and Kunle O.O. Evaluation of disintegrant properties of Neorautanenia mitis starch. Journal of Phytomedicine and Therapeutics. 2016; 15, 52-63
Bakre L., Osibajo D., Koiki G. and Bamiro O. Material, Compressional and tableting properties of Ipomea batatas (Sweet potato) starch co-processed with silicon dioxide. Acta Pharmaceutical Sciencia. 2019; 57, 21-37
Rambabu S., Ranawat M.S., Bhandari A. and Dinesh P. The study of Guar gum and starch on disintegration time and drug release of fast dissolving tablet in rabbit using single dose randomized parallel design method. Jordan Journal of Pharmaceutical Sciences. 2013; 6 (3):280-291
Kumar R., Patil M.B., Patil S.R. and Paschapur M.S. Evaluation of Abelmoschus esculentus mucilage as suspending agent in paracetamol suspension. Int. J. PharmTech. Res. 2009; 1: 658–665.
Manek R.V., Builders P.F., Kolling W.M., Emeje M. and Kunle, O.O. Physicochemical and binder properties of starch obtained from Cyperus esculentus. AAPS PharmSci Tech. 2012; 13 (2), 379-388
World Health Organization (2011). Metronidazole oral suspension. Adopted text for addition to The International Pharmacopoeia. Accessed on 16th November 2020. Available on https://www. who.int/ medicines/publications/pharmacopoeia/MetronidazoleOralSusp-QAS10 346FINAL.pdf?
Bamiro O.A., Ajala T.O., Uwaezuoke O.J. and Akinwumi A.G. The suspending properties of Terminalia randii gum in magnesium carbonate suspension. African Journal of Pharmacy and Pharmacology. 2014; 8(3):87-92.
Oppong E.E., Osei-Asare C., Klu M.W. Evaluation of the suspending properties of shea tree gum. International Journal of Pharmacy and Pharmaceutical Sciences. 2016; 8(7): 409-413
Aremu O.I and Oduyela O.O. Evaluation of metronidazole suspensions. African Journal of Pharmacy and Pharmacology. 2015; 9(12): 439–450.
Bakre L. and Ajakore O. Suspending properties of natural gums extracted from Abelmuscus esculentus pod and Chrysophyllum albidium fruit. African Journal of Pharmacy and Pharmacology. 2015; 9 (10): 321-326
Deicke A, and Suverkrup R. Dose uniformity and redispersibility of pharmaceutical suspensions II: assessment of three commercial erythromycin ethyl succinate oral liquids. European Journal of Pharmacy and Biopharmaceutics. 2000; 49: 73–78.
Brhane Y. Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations. PLOS ONE. 2020; https://doi.org/10.1371/journal.pone.0228547
