تقييم Basella alba L Mucilage كعامل تعليق في تعليق ميترونيدازول
DOI:
https://doi.org/10.35516/jjps.v15i3.418الكلمات المفتاحية:
Basella alba، معلق، عوامل تعليق، ميترونيدازولالملخص
في البحث عن بوليمرات طبيعية قابلة للتحلل وغير سامة لاستخدامها كسواغات في المستحضرات الصيدلانية، تم عزل الصمغ من جذع Basella alba L (BAM) وتقييمه كعامل معلق في معلقات الميترونيدازول بتركيزات مختلفة (0.5٪ - 2٪ وزن / ت) بالمقارنة مع تراجاكانث (TCG) ولثة الجيلاتين (GLT). تم تحديد الخواص الميكروميريتية لمسحوق الصمغ وتم تمييز معلق الميترونيدازول باستخدام معدل التدفق وعدد إعادة التشتت وحجم الترسيب واللزوجة ودرجة الحموضة. تم تحديد درجة التندف أيضًا. مسحوق BAM له خاصية تدفق جيدة مع الحد الأدنى من التورم. كان ترتيب معدل تدفق معلق الميترونيدازول BAM = TCG> GLT بينما كان ترتيب حجم الترسيب TCG> BAM> GLT. لم يكن هناك فرق كبير (p> 0.05) في عدد إعادة تشتت تركيبات BAM و TCG. كانت لزوجة التركيبات المحتوية على BAM و TCG بتركيزات 0.5٪ -1.0٪ وزن / حجم هي نفسها. تراوح الأس الهيدروجيني للمعلقات من 5 إلى 8. كانت درجة التلبد بالترتيب GLT> BAM> TCG. من النتائج التي توصلنا إليها، يمكن استخدام BAM كعامل تعليق بديل في صياغة التعليق.
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