التأثير المزيل للقلق للمستخلص الكحولي الإثانولي لتمر المجهول على الفئران المخبرية
DOI:
https://doi.org/10.35516/jjps.v16i1.1035الكلمات المفتاحية:
القلق، متاهة الصفر المرتفعة، فينيكس داكتيليفيرا، دفن كرات الرخام، تمر المجهولالملخص
الخلفية: القلق هو أحد الاضطرابات النفسية الأكثر شيوعًا، حيث يصيب 33.7٪ من عامة السكان. ومع ذلك، فقد وجد أن استهلاك الأنظمة الغذائية الصحية يساعد، على الأقل جزئيًا، في الوقاية من الاضطرابات الشبيهة بالقلق وعلاجها.
الطرق البحثية: في هذه الدراسة، تم تقييم سلوكيات القلق لدى الفئران التي تعرضت للتناول المزمن لجرعات منخفضة وعالية من المستخلص الكحولي لتمور المجهول (Phoenix Dactylifera) مقارنة بنظيراتها من الفئران الضابطة التي لم تتناول التمر. تم استخدام اختبار ارتفاع متاهة الصفر واختبار دفن كرات الرخام كنماذج مفضلة لتقييم سلوكيات القلق لدى هذه الفئران. بالإضافة إلى ذلك، تم إجراء تحليل كيميائي نباتي لمجموعات الأيض الثانوية الرئيسية لمستخلص تمر المجهول.
النتائج: بينت نتائج هذه الدراسة أن مستخلص تمر المحهول غني بالفلافونويد والستيرويدات مع نشاط معروف باسم مزيلات القلق مثل الكايمفيرول. أظهرت الفئران التي تلقت جرعة منخفضة (300 مجم / كجم) من المستخلص قلقًا أقل من خلال استخدام اختبار ارتفاع متاهة الصفر من الفئران التي لم تتناول مستخلص التمر، والذي تم تحديده من خلال زيادة كبيرة في زمن الوصول إلى المنطقة المغلقة و انخفاض كبير في الوقت الذي يقضيه في المنطقة المغلقة و أيضا زيادة كبيرة في عدد الإدخالات إلى الأرباع المفتوحة. كان تأثير مزيل القلق لمستخلص التمر من الجرعة المنخفضة مشابهًا للتأثير الناتج في الفئران التي عولجت بالديازيبام (1.5 مجم / كجم) في جميع المتغيرات المختبرة الدالة على مستوى القلق. باللإضافة إلى ما سبق، أظهرت نتائج اختبار دفن كرات الرخام فرقا احصائيا في إزالة القلق بجرعة منخفضة (300 مجم / كجم) من مستخلص التمر مقارنة بالفئران التي لم تتناول مستخلص التمر، والذي تبيين من خلال إنخفاض في العدد الإجمالي لكرات الرخام المدفون. إضافة إلى ذلك، كان التأثير المزيل للقلق لمستخلص التمر من الجرعة المنخفضة في اختبار دفن كرات الرخام مشابهًا للتأثير الناتج في الفئران التي عولجت بفلوكستين (5 مجم / كجم). من ناحية أخرى، فإن تناول جرعات عالية من مستخلص التمر (2583 مجم / كجم) لم يسبب أي تأثير مزيل للقلق في متاهة الصفر المرتفعة واختبارات دفن كرات الرخام.
الاستنتاجات: بشكل عام، تشيرالنتائج هذه الدراسة إلى أن تناول جرعة منخفضة بانتظام من المستخلص الكحولي من التمر المجهول قد يساعد في منع وإدارة اضطرابات القلق. ومع ذلك، يوصى بإجراء مزيد من الدراسات لتوضيح الآلية المفترضة الكامنة وراء التأثير المزيل للقلق لدى تمر المجهول.
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