Identification of Pharmaceutically Important Constituents of Quinoa Root
DOI:
https://doi.org/10.35516/jjps.v16i1.1071Keywords:
Bioactive constituents, Chenopodium quinoa, n-hexane extract, GC-MS analysis, rootAbstract
The present investigation was carried out to explore the bioactive compounds from the n-hexane fraction of methanolic extract of quinoa (Chenopodium quinoa Willd.) roots. For this purpose, C. quinoa roots were collected, shade dried, and crushed into a fine powder. The powdered material was extracted in methanol, filtered, and the filtrate was partitioned with n-hexane, followed by GC-MS analysis of the n-hexane fraction. The quantitative determination of this fraction revealed the presence of 15 phytochemical constituents of diverse nature. Among these, octadec-9-enoic acid (44.18%); n-hexadecanoic acid (18.87%); methyl (Z)-octadec-9-enoate (12.87%); methyl hexadecanoate (4.30%); 2,3-dihydroxypropyl elaidate (3.63%); phthalic acid (3.08%); methyl octadecanoate (2.27%) and 1,12-tridecadiene (2.00%) were prevailing as the most abundant to moderately occurring compounds. A thorough literature survey was carried out to collect information regarding the pharmaceutical properties of the identified compounds. It showed some of the identified compounds namely dodecanoic acid; tetradecanoic acid; 2-benzoyl-d-galactosan; n-hexadecanoic acid; methyl octadecanoate; octadec-9-enoic acid; and 2,3-dihydroxypropyl elaidate possess antifungal, antibacterial, antioxidant, antiviral, anti-inflammatory, and/or anti-cancer properties.
References
Malik K, Ahmad M, Zhang G, et al.Traditional plant-based medicines used to treat musculoskeletal disorders in Northern Pakistan. Eur J Integr Med 2018);19: 17-64.
Khan IH, Javaid A, Anticancer, antimicrobial and antioxidant compounds of quinoa inflorescence. Adv Life Sci 2020;8(1): 68-72.
Khan IH, Javaid A, Antifungal, antibacterial and antioxidant components of ethyl acetate extract of quinoa stem. Plant Prot 2019;3(3): 125-30.
Ncama K, Mditshwa A, Tesfay SZ, et al.Topical procedures adopted in testing and application of plant-based extracts as bio-fungicides in controlling postharvest decay of fresh produce. Crop Prot 2019;115: 142-51.
Khan IH, Javaid A, Identification of biologically important compounds in neem leaves through GC-MS analysis. Jordan j pharm. Sci., 2021;14: 359-66
Khan IH, Javaid A, Antifungal activity and GC-MS analysis of n-butanol extract of quinoa leaves. Bangladesh J Bot 2020;49(4): 1045-51.
Mitrani E, Perdum E, Iordache OG, et al.Advantages and disadvantages of pesticide analysis methods used in agricultural samples. Sci Papers-Series B-Hortic 2018;62: 709-14.
Irianti T, Pratiwi SUT, Yasmin IF, Antituberculosis activity of active compound of ethyl acetate extract for patikan kebo (Euphorbia hirta L.). Jordan j. pharm. sci 2022; 15: 461-473.
Banaras S, Javaid A, Khan IH, Bioassays guided fractionation of Ageratum conyzoides extract for the identification of natural antifungal compounds against Macrophomina phaseolina. Int J Agric Biol 2021; 25(4): 761-7.
Javed S, Javaid A, First report of black rot of carrot caused by Alternaria radicina in Pakistan. J Anim Plant Sci 2021; 31(4): 1208-11.
Hinojosa L, Matanguihan JB, Murphy KM, Effect of high temperature on pollen morphology, plant growth and seed yield in quinoa (Chenopodium quinoa Willd.). J Agron Crop Sci 2019;205: 33-45.
Maughan PJ, Chaney L, Lightfoot DJ, et al.itochondrial and chloroplast genomes provide insights into the evolutionary origins of quinoa (Chenopodium quinoa Willd.). Sci Rep 2019;9: 185.
Hernandez-Ledesma B, Quinoa (Chenopodium quinoa Willd.) as source of bioactive compounds: A review. Bioact Compd Health Dis 2019;2: 27-47.
Manaa A, Goussi R, Derbali W, et al.Salinity tolerance of quinoa (Chenopodium quinoa Willd) as assessed by chloroplast ultrastructure and photosynthetic performance. Environ Exp Bot 2019;162: 103-14.
Javaid A, Chaudhury FA, Khan IH, et al.Potential health-related phytoconstituents in leaves of Chenopodium quinoa. Adv Life Sci 2022; 9(4): 574-578.
Khan IH, Javaid A, Ahmed D, et al.Pesticidal constituents in n-hexane inflorescence extract of Chenopodium quinoa. Mycopath 2018,16(1): 43-6.
Banaras S, Javaid A, Khan IH, Potential antifungal constituents of Sonchus oleraceous against Macrophomina phaseolina. Int J Agric Biol 2020;24(5): 1376-1382.
Khan IH, Javaid A, Comparative antifungal potential of stem extracts of four quinoa varieties against Macrophomina phaseolina. Int J Agric Biol 2020;24(3): 441-446.
Dubal KN, Ghorpade PN, Kale MV, Studies on bioactive compounds of Tectaria coadunata (Wall. Ex Hook. & Grev.). Asian J Pharm Clin Res 2013;6: 185-187.
Rani SVG, Murugaiah K, GC-MS determination of bioactive compounds in Azima tetracantha leaves. World J Pharm Res 2015;4: 2225-31.
Elaiyaraja A, Chandramohan G. Comperative phytochemical profile of Indoneesiella echioides (L.) Nees leaves using GC-MS. J Pharmacogn Phytochem 2016;5: 158-171.
Igwe OU, Abii T. Characterization of bioactive sesquiterpenes, organic acids and their derivatives from the leaves of Psidium guajava Linn. Int Res J Pure Appl Chem 2014;4: 456-67.
Abdel-Wahhab MA, Ahmed HM, Abdel-Aziem SH, et al. Modulation of hepatotoxicity, DNA fragmentation and gene expression of Solanum nigrum leaves extract in rats treated with silver nanoparticles. J Appl Pharm Sci 2017;7: 25-35.
Sosa AA, Bagi SH, Hameed IH, Analysis of bioactive chemical compounds of Euphorbia lathyrus using gas chromatography-mass spectrometry and fourier-transform infrared spectroscopy. J Pharmacog Phytother 2016; 8: 109-26.
Ujowundu FN, Ojiako AO, Nwaoguikpe RN, Ujowundu CO, Gas chromatography-mass spectrometry and infra-red studies of bioactive phytoorganic components of Combretum dolichopentalum Leaves. Int J Drug Dev Res 2017;9: 10-5.
Odumosu BT, Salawu OT, Oyeyemi I, et al. Bioactive constituents and antibacterial screening of two Nigerian plant extracts against selected clinical bacteria. Niger J Pharm Res 2018; 12: 127-37.
Queiroz DD, Sales DL, Andrade JC. Antibacterial and antibiotic modifying activity evaluation of ruminants' body fat used as zoo therapeutics in ethnoveterinary practices in Northeast Brazil. J Ethnopharmacol 2019; 233: 87-93.
Vijayakumar S, Yabesh JM, Arulmozhi P, et al.Identification and isolation of antimicrobial compounds from the flower extract of Hibiscus rosa-sinensis L: In silico and in vitro approaches. Microb Pathog 2018;123: 527-35.
Waqas HM, Akbar M, Khalil T, et al. Identification of natural antifungal constituents from Agaricus bisporus (je lange) Imbach. Appl Ecol Env Res 2018;16: 7937-51.
Kanhar S, Sahoo AK, Ameliorative effect of Homalium zeylanicum against carbon tetrachloride-induced oxidative stress and liver injury in rats. Biomed Pharmacother 2019;111: 305-14.
Ozen T, Zenginbal H, Yazicioglu E, et al. comparison investigation on antioxidant activities, physicochemical properties and phytochemical contents of kiwifruit genotypes and cultivars. Int J Fruit Sci 2019;19: 115-35.
Abu-Rumman AM, Gas chromatography-mass spectrometry (GC-MS) analysis of extracted oil from whole garden cress (Rashaad) seeds. Am J Eng Res 2018;7: 1-8.
Gnanasundaram I, Balakrishnan K, Characterization of bioactive compounds in ethanolic extract of Cissus vitiginea leaves using GC-MS technique. IOSR J Appl Chem 2017;10: 24-7.
Yamuna P, Abirami P, Sharmila M, et al.GC-MS analysis of bioactive compounds in the entire parts of ethanolic extract of Gomphrena globosa Linn. Int J Res Pharm Pharm Sci 2017;2: 57-64.
Jenecius A, Uthayakumaria F, Mohan VR, GC-MS determination of bioactive components of Sauropus bacciformis blume (Euphorbiaceae). J Curr Chem Pharm Sci 2012;2: 347-58.