أظهر مستخلص أوراق الميثانول من Zingiber officinale (ginger) تأثيرًا مضادًا للسمنة في فئران Wistar التي تتغذى على نظام غذائي عالي الدهون
DOI:
https://doi.org/10.35516/jjps.v16i4.1128الكلمات المفتاحية:
نبات الزنجبيل، وزن الجسم، الأنسجة الدهنية، السيتوكينات، أورليستات، الأديبوكينات، مضادات الأكسدةالملخص
قيمت هذه الدراسة خاصية مكافحة السمنة لمستخلص الميثانول من أوراق Zingiber officinale في فئران Wistar. تم توزيع ثلاثين من ذكور الجرذان في خمس مجموعات مع ستة فئران في كل مجموعة وعولجت مجموعات مختلفة بنظام غذائي طبيعي للدهونNFD ) ، نظام غذائي عالي الدهون ( HFD ), HFD + orlistat ( 20 مجم / كجم ) p.o ، HFD + Zingiber officinale ( 200 مجم / كجم ) p.o و HFD + Zingiber officinale (. بعد جميع الإدارات ، تم التضحية بالحيوانات عن طريق خلع عنق الرحم وأجريت تحليلات كيميائية حيوية مختلفة. أظهرت النتائج أنه كان هناك انخفاض كبير (p ug 0.05 ) في وزن الجسم والسمعة في مجموعات Zingiber officinale و NFD و orlistat مقارنة مع التحكم في HFD. ومع ذلك ، لم يكن هناك فرق كبير في أوزان الجسم للفئران في مجموعات Zingiber officinale مقارنة مع مجموعات NFD للتحكم و orlistat. علاوة على ذلك ، كان لدى الفئران في مجموعات Zingiber officinale تركيزات دهنية طبيعية، وحالة مضادة للأكسدة، والأديبوكينات، والسيتوكينات، والكبد، معلمات وظائف الكلى والقلب التي يمكن مقارنتها مع أورليستات والتحكم الطبيعي ولكن على النقيض من التحكم HFD. تشير نتائج الدراسة إلى أن أوراق Zingiber officinale لها خصائص كبيرة مضادة للسمنة ومضادات الأكسدة ومضادة للالتهابات.
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