التداخلات الدوائية المحتملة والمتنبّئات المرتبطة بحدوثها في مشفى الأطفال الجامعي في سورية: دراسة مقطعية
DOI:
https://doi.org/10.35516/jjps.v17i1.1606الكلمات المفتاحية:
التداخلات دوائية، طب الأطفال، الأطفال في المشفى، مأمونية الدوائية، سوريةالملخص
هدف الدراسة: إعطاء الأدوية المتعددة للأطفال المرضى ممارسة شائعة وتُعرّض الأطفال لخطر التداخلات الدوائية (DDIs). تهدف هذه الدراسة إلى توصيف الـ DDIs المحتملة (pDDIs) وعوامل الخطورة المرتبطة بها لدى الأطفال المقبولين في المستشفى.
المنهج البحثي: أجريت دراسة مقطعية لمدة 6 أشهر في مشفى الأطفال الجامعي بدمشق. ضمّت الدراسة 577 طفلاً يتلقون دواءين أو أكثر. استُخدم برنامج Lexi-Interact® لتحرّي pDDIs. شمل التحليل الـ pDDIs من الفئات: B (لا حاجة لاتخاذ إجراء)، C (مراقبة المعالجة)، D (تعديل الجرعات)، وX (تجنب المشاركة). استُخدم الانحدار اللوجستي لتحديد عوامل الخطورة المرتبطة بـ DDIs.
النتائج: تم الكشف عن وجود pDDI واحد على الأقل لدى 49.7% من الأطفال. بلغ عدد الــ pDDIs ما مجموعه 744 تداخلاً دوائياً. تنتمي معظم الـ pDDIs إلى فئة الخطورة C (71.6%)، تليها التداخلات من الفئة D (14%)، B (12.8%) وX (1.6%). أكثر الـ pDDIs تكراراً: الأمينوغليكوزيدات - البنسلينات (56 مشاركة)، الأمينوغليكوزيدات - السيفالوسبورينات (27 مشاركة) و فيتامين د - أملاح الكالسيوم (23 مشاركة). شملت العوامل المؤثرة على وجود pDDIs كلاً من عدد الأدوية الموصوفة ووصف دواء من زمرة الأدوية العصبية.
الاستنتاجات: معدّل الـ pDDIs لدى الأطفال في المشفى مرتفع. معظم الـ pDDIs من فئة الخطورة C، مما يستدعي مراقبة العلاج واتخاذ الإجراء المناسب لتجنب التبعات الضارة.
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