تحسين وسيلة توصيل الدواء باستخدام اختيار المواد المساعدة المبني على قرارات متعددة المعايير MCDM))

المؤلفون

  • Ibrahim Omoyayi قسم الهندسة الطبية الحيوية، كلية الهندسة، جامعة الشرق الأدنى، نيقوسيا، مرسين 10، تركيا
  • Süleyman Aşır قسم الهندسة الطبية الحيوية، كلية الهندسة، جامعة الشرق الأدنى، نيقوسيا، مرسين 10، تركيا
  • Abdullahi U. Ibrahim قسم الهندسة الطبية الحيوية، كلية الهندسة، جامعة الشرق الأدنى، نيقوسيا، مرسين 10، تركيا

DOI:

https://doi.org/10.35516/jjps.v17i1.1692

الكلمات المفتاحية:

اتخاذ القرار متعدد المعايير (MCDM)، مادة مساعدة حاملة للدواء، الذوبانية، التوافر الحيوي

الملخص

تُستخدم المواد المساعدة في أنظمة توصيل الدواء كوسيلة لتوصيل الأدوية بفعالية إلى موقعها المستهدف. تُعد طرق اتخاذ القرار متعددة المعاييرMCDM) ) أدوات لاتخاذ القرارات التي يمكن أن تضع في الاعتبار العوامل متعددة الأبعاد بالإضافة إلى التكنولوجيا المقارنة المستخدمة في الطب مع مزيج من المعايير الفردية في التقييم الكلي للبدائل المختارة. تهدف هذه الدراسة إلى تحسين الذوبانية والتوافر الحيوي للأدوية من خلال تطبيق اختيار المواد المساعدة المستند إلى MCDM. من خلال دمج طريقة ترتيب التفضيلات لتقييمات التحسين (PROMETHEE الضبابي)، يمكن تقييم المواد المساعدة المختلفة وترتيبها بناءً على مدى ملاءمتها للتطبيق المحدد، مع الأخذ في الاعتبار المعايير المتعلقة بذوبانية الدواء وتوافره الحيوي. تسلط النتائج الضوء على إمكانات السيكلودكسترين (صافي التدفق: 0.0023) وبوليمرات اليودراجيت (صافي التدفق: 0.0016) كخيارات مفضلة لحاملات الدواء، بينما يتم تحديد بولوكسامر 188 (P188)  (صافي التدفق: -0.0030) كأقل خيار مفضل. تُظهر هذه الدراسة فعالية طريقة PROMETHEE الضبابي في تحسين أداء الأدوية ذات الذوبانية والتوافر الحيوي المنخفض، مما يساهم في النهاية في تطوير أنظمة توصيل الدواء الجديدة. تتمتع النتائج بأهمية كبيرة للنتائج العلاجية في علاج الأمراض.

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التنزيلات

منشور

2024-03-19

كيفية الاقتباس

Omoyayi, I., Aşır, S., & Ibrahim, A. U. (2024). تحسين وسيلة توصيل الدواء باستخدام اختيار المواد المساعدة المبني على قرارات متعددة المعايير MCDM)). Jordan Journal of Pharmaceutical Sciences, 17(1), 55–67. https://doi.org/10.35516/jjps.v17i1.1692

إصدار

القسم

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