تحضير وتوصيف حبيبات هلامية مائية تحرِّر الأموكسيسيلين بشكل مضبوط
DOI:
https://doi.org/10.35516/jjps.v15i4.675الكلمات المفتاحية:
إيتاء الأدوية بشكل مضبوط، ألجينات الصوديوم، الحبيبات الهلامية المائية، البولوكزامير 407، الأموكسيسيلينالملخص
تصف هذه الدراسة تحضير وتوصيف الحبيبات الهلامية المائية والمحمَّلة بالأموكسيسيلين ثلاثي الماء، وذلك بهدف استعمالها كنظام إيتاء مضبوط من أجل تحسين مطاوعة المريض. تم تحضير الحبيبات الهلامية المائية بطريقة التهلم الأيوني، وذلك باستخدام كلوريد الكالسيوم كعامل مصالِب CaCl2)). تمت دراسة تأثير تركيز كلاً من CaCl2 والجينات الصوديوم والبولوكزامير 407 ودرجة حرارة التحضير. تم الحول على حبيبات هلامية مائية كروية الشكل مع كفاءة كبسلة عالية (85.74 ± 1.09) ٪. أثبت تحليل FTIR التوافق ما بين السواغات والأموكسيسيلين. تم إجراء كلاً من اختبار الانتباج والتحرر التراكمي للدواء في وسط HCl (pH=1.2) خلال 24 ساعة. أثّرت درجة حرارة التحضير معنوياً على كلاً من منسب الانتباج والتحرر التراكمي للأموكسيسيلين. ساهم الـ PL في زيادة التحرر التراكمي للأموكسيسيلين، وتوافق ذلك مع دراسة الانتباج. يمكن اعتبار هذه الحبيبات الهلامية المائية الجديدة نظام إيتاء واعد، يحرر الأموكسيسيلين بشكل مضبوط خلال 24 ساعة ويقلل عدد مرات التجريع.
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