مثبط :JNK نهج جديد لتنظيم الحرائك الدوائية للفينلافاكسين
DOI:
https://doi.org/10.35516/jjps.v16i3.718الكلمات المفتاحية:
التمثيل الغذائي، الحرائك الدوائية، العلاج بمضادات الاكتئاب، نقل الإشارات داخل الخلايا، JNKالملخص
تمت دراسة تأثير مثبط JNK "IQ-1" على الحرائك الدوائية لمضاد الاكتئاب فينلافاكسين. تم الكشف عن تسارع عملية التمثيل الغذائي لهذا العامل المؤثر عقليًا عندما تم إعطاء معدل نقل الإشارة داخل الخلايا لحيوانات التجارب في الجسم الحي. ترافق حصار JNK مع انخفاض في مستوى البلازما لمضاد الاكتئاب دون تغييرات في تركيز المستقلب النشط دوائيًا O-desmethylvenlafaxine. تشير النتائج التي تم الحصول عليها إلى تعديل نمط التحول الحيوي للفينلافاكسين (والذي يتكون من تغيير في المسارات الأيضية مع زيادة تكوين المستقلبات الأخرى) أو تصحيح توزيعه في الجسم. يمكن استخدام الخصائص التي تم الكشف عنها لمثبط JNK لتطوير مناهج جديدة بشكل أساسي لتحسين فعالية العلاج المضاد للاكتئاب باستخدام فينلافاكسين في إطار تنفيذ "استراتيجية التنظيم المستهدف لعملية التمثيل الغذائي للأجسام الحيوية وحركية الدواء".
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