تأثير المانيتول على وظائف الكلى أثناء جراحة القلب وبعدها مباشرة في مستشفيات خاصة مختارة في مدينة نابلس/ فلسطين.
DOI:
https://doi.org/10.35516/jjps.v18i2.2640الكلمات المفتاحية:
الكرياتينين، المانيتول، مجازة القلب والرئة، جراحة القلب، وظائف الكلىالملخص
الخلفية: تُعد مجازة القلب والرئة (CPB) تقنية شائعة في جراحة القلب، إلا أنها ترتبط بإصابة كلوية حادة. يمكن أن يؤثر نوع المحلول في دائرة مجازة القلب والرئة على نتائج الجراحة من خلال التأثير على العديد من الأعضاء وتوازن الجسم. لم يُحدد بعد المحلول الأولي الأمثل لدائرة مجازة القلب والرئة في جراحة القلب للبالغين. يُستخدم المانيتول على نطاق واسع في محلول التحضير لمجازة القلب والرئة، على الرغم من عدم وجود إجماع واضح على دوره في جراحة القلب.
الغرض: هدفت هذه الدراسة إلى دراسة تأثير المانيتول في محلول مجازة القلب والرئة الأولي على وظائف الكلى أثناء جراحة القلب وبعدها في مستشفيات خاصة مختارة في مدينة نابلس.
التصميم والمنهجية: تصميم دراسة أترابية مستقبلية أُجريت في مستشفى النجاح الوطني الجامعي ومستشفى العربي التخصصي. دُرست عينة من 120 مريضًا. خضع المرضى لجراحة قلب، وكانت وظائف الكلى لديهم طبيعية قبل الجراحة. النتائج: ارتبط استخدام المانيتول في محلول CPB الرئيسي بانخفاض مستويات قراءات الكرياتينين والنيتروجين في الدم خلال فترة ما بعد الجراحة (متوسط فترة ما بعد الجراحة = 0.7692 ± 0.26068، و18.3917 ± 7.56629 ملغ/ديسيلتر، على التوالي؛ قيمة p <0.001) وزيادة في مستويات معدل الترشيح الكبيبي خلال فترة ما بعد الجراحة (متوسط فترة ما بعد الجراحة = 112.27861 ± 1.43604، قيمة p <0.001) مما يشير إلى تحسن في وظائف الكلى بعد جراحة القلب
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