التقييم الدوائي الحركي للنياسين والبتيروستيلبين في الجرعات المفردة والمتعددة لدى الأشخاص الأصحاء

Tsai H-Y, Ho C-T, Chen Y-K. Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene. Journal of food and drug analysis. 2017; 25(1): 134-47. DOI: https://doi.org/10.1016/j.jfda.2016.07.004

Singh CK, Liu X, Ahmad N. Resveratrol, in its natural combination in whole grape, for health promotion and disease management. Annals of the New York Academy of Sciences. 2015; 1348(1): 150-60. DOI: https://doi.org/10.1111/nyas.12798

Sharma S, K Sahni J, Ali J, Baboota S. Patent perspective for potential antioxidant compounds-rutin and quercetin. Recent Patents on Nanomedicine. 2013; 3(1): 62-8. DOI: https://doi.org/10.2174/18779123112029990002

Qamar A. Antidiabetic activity, polyphenols-based characterization and molecular interaction of extract of un-ripe pods of Vinca rosea cv. Pink. Jordan Journal of Pharmaceutical Sciences. 2022; 15(2): 158-72. DOI: https://doi.org/10.35516/jjps.v15i2.303

AlSaleh A, Shahid M, Farid E, Bindayna K. The Effect of Ascorbic Acid and Nicotinamide on Panton–Valentine Leukocidin Cytotoxicity: An Ex Vivo Study. Toxins. 2023; 15(1): 38. DOI: https://doi.org/10.3390/toxins15010038

Rehman IU, Ahmad R, Khan I, Lee HJ, Park J, Ullah R, et al. Nicotinamide ameliorates amyloid beta-induced oxidative stress-mediated neuroinflammation and neurodegeneration in adult mouse brain. Biomedicines. 2021; 9(4): 408. DOI: https://doi.org/10.3390/biomedicines9040408

Montecucco F, Quercioli A, Dallegri F, Viviani GL, Mach F. New evidence for nicotinic acid treatment to reduce atherosclerosis. Expert review of cardiovascular therapy. 2010; 8(10): 1457-67. DOI: https://doi.org/10.1586/erc.10.116

Ganji SH, Kamanna VS, Kashyap ML. Niacin and cholesterol: role in cardiovascular disease (review). The Journal of nutritional biochemistry. 2003; 14(6): 298-305. DOI: https://doi.org/10.1016/S0955-2863(02)00284-X

van der Hoorn JW, de Haan W, Berbée JF, Havekes LM, Jukema JW, Rensen PC, et al. Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE* 3Leiden. CETP mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008; 28(11): 2016-22. DOI: https://doi.org/10.1161/ATVBAHA.108.171363

Arauz J, Rivera-Espinoza Y, Shibayama M, Favari L, Flores-Beltrán RE, Muriel P. Nicotinic acid prevents experimental liver fibrosis by attenuating the prooxidant process. International immunopharmacology. 2015; 28(1): 244-51. DOI: https://doi.org/10.1016/j.intimp.2015.05.045

Carlson L. Niaspan, the prolonged release preparation of nicotinic acid (niacin), the broad‐spectrum lipid drug. International journal of clinical practice. 2004; 58(7): 706-13. DOI: https://doi.org/10.1111/j.1368-5031.2004.00233.x

Kapetanovic IM, Muzzio M, Huang Z, Thompson TN, McCormick DL. Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer chemotherapy and pharmacology. 2011; 68(3): 593-601. DOI: https://doi.org/10.1007/s00280-010-1525-4

Lin HS, Yue BD, Ho PC. Determination of pterostilbene in rat plasma by a simple HPLC‐UV method and its application in pre‐clinical pharmacokinetic study. Biomedical Chromatography. 2009; 23(12): 1308-15. DOI: https://doi.org/10.1002/bmc.1254

Li YR, Li S, Lin CC. Effect of resveratrol and pterostilbene on aging and longevity. Biofactors. 2018; 44(1): 69-82. DOI: https://doi.org/10.1002/biof.1400

Cicero AF, Colletti A. Combinations of phytomedicines with different lipid lowering activity for dyslipidemia management: the available clinical data. Phytomedicine. 2016; 23(11): 1113-8. DOI: https://doi.org/10.1016/j.phymed.2015.10.011

Badimon L, Vilahur G, Padro T. Nutraceuticals and atherosclerosis: human trials. Cardiovascular Therapeutics. 2010; 28(4): 202-15. DOI: https://doi.org/10.1111/j.1755-5922.2010.00189.x

Heeba GH, Abd-Elghany MI. Effect of combined administration of ginger (Zingiber officinale Roscoe) and atorvastatin on the liver of rats. Phytomedicine. 2010; 17(14): 1076-81. DOI: https://doi.org/10.1016/j.phymed.2010.04.007

Cicero AFG, Colletti A, Fogacci F, Bove M, Rosticci M, Borghi C. Effects of a combined nutraceutical on lipid pattern, glucose metabolism and inflammatory parameters in moderately hypercholesterolemic subjects: a double-blind, cross-over, randomized clinical trial. High Blood Pressure & Cardiovascular Prevention. 2017; 24(1): 13-8. DOI: https://doi.org/10.1007/s40292-016-0163-2

Bahiru E, de Cates AN, Farr M, Jarvis MC, Palla M, Rees K, et al. Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular diseases. Cochrane Database Syst Rev. 2017; 3: CD009868. DOI: https://doi.org/10.1002/14651858.CD009868.pub3

Qureshi AA, Khan DA, Mahjabeen W, Papasian CJ, Qureshi N. Suppression of nitric oxide production and cardiovascular risk factors in healthy seniors and hypercholesterolemic subjects by a combination of polyphenols and vitamins. Journal of clinical & experimental cardiology. 2012: 008. DOI: https://doi.org/10.4172/2155-9880.S5-008

Ricardo KFS, Oliveira TTd, Nagem TJ, Pinto AdS, Oliveira MGA, Soares JF. Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton. Brazilian Archives of biology and technology. 2001; 44(3): 263-7. DOI: https://doi.org/10.1590/S1516-89132001000300007

Preuss HG, Wallerstedt D, Talpur N, Tutuncuoglu SO, Echard B, Myers A, et al. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. Journal of medicine. 2000; 31(5-6): 227-46.

Ravi VB, Mullangi R, Inamadugu JK, Pilli NR, Gajula R, Ponneri V. Simultaneous determination of atorvastatin and niacin in human plasma by LC‐MS/MS and its application to a human pharmacokinetic study. Biomedical Chromatography. 2012; 26(11): 1436-43. DOI: https://doi.org/10.1002/bmc.2715

Dellinger RW, Santos SR, Morris M, Evans M, Alminana D, Guarente L, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ aging and mechanisms of disease. 2017; 3(1): 17. DOI: https://doi.org/10.1038/s41514-017-0016-9

Riche DM, McEwen CL, Riche KD, Sherman JJ, Wofford MR, Deschamp D, et al. Analysis of safety from a human clinical trial with pterostilbene. Journal of toxicology. 2013; 2013. DOI: https://doi.org/10.1155/2013/463595

Jia Y-y, Ying S, Lu C-t, Yang J, Ding L-k, Wen A-d, et al. Pharmacokinetics of single-dose and multi-dose of lovastatin/niacin ER tablet in healthy volunteers. Chromatography Research International. 2012; 2012. DOI: https://doi.org/10.1155/2012/437075

Gelijkens C, De Leenheer A. Reversed-phase liquid chromatography of 5-fluoro-uracil nucleosides and nucleotides in the presence of quaternary ammonium ions. Journal of Chromatography A. 1980; 194(3): 305-14. DOI: https://doi.org/10.1016/S0021-9673(00)81421-1

Xu H, Paxton J, Lim J, Li Y, Wu Z. Development of a gradient high performance liquid chromatography assay for simultaneous analysis of hydrophilic gemcitabine and lipophilic curcumin using a central composite design and its application in liposome development. Journal of pharmaceutical and biomedical analysis. 2014; 98: 371-8. DOI: https://doi.org/10.1016/j.jpba.2014.06.022

Wang Y, Lu X, Xu G. Simultaneous separation of hydrophilic and hydrophobic compounds by using an online HILIC‐RPLC system with two detectors. Journal of separation science. 2008; 31(9): 1564-72. DOI: https://doi.org/10.1002/jssc.200700663

Arroyo-Abad U, Lischka S, Piechotta C, Mattusch J, Reemtsma T. Determination and identification of hydrophilic and hydrophobic arsenic species in methanol extract of fresh cod liver by RP-HPLC with simultaneous ICP-MS and ESI-Q-TOF-MS detection. Food chemistry. 2013; 141(3): 3093-102. DOI: https://doi.org/10.1016/j.foodchem.2013.05.152

Zhang X, Rauch A, Lee H, Xiao H, Rainer G, Logothetis NK. Capillary hydrophilic interaction chromatography/mass spectrometry for simultaneous determination of multiple neurotransmitters in primate cerebral cortex. Rapid Communications in Mass Spectrometry. 2007; 21(22): 3621-8. DOI: https://doi.org/10.1002/rcm.3251

Hung C, Taylor R. Mechanism of retention of acidic solutes by octadecyl silica using quaternary ammonium pairing ions as ion exchangers. Journal of Chromatography A. 1980; 202(3): 333-45. DOI: https://doi.org/10.1016/S0021-9673(00)91817-X

Wade C, Jackson P, Van Rij A. Quantitation of malondialdehyde (MDA) in plasma, by ion-pairing reverse phase high performance liquid chromatography. Biochemical medicine. 1985; 33(3): 291-6. DOI: https://doi.org/10.1016/0006-2944(85)90003-1

Guideline IHT. Validation of analytical procedures: text and methodology. Q2 (R1). 2005; 1.

Fahdawi A, Shalan N, Lafi Z, Markab O. Analytical Approaches for Assessing Curcumin and Nicotinamide Co-Encapsulated in Liposomal Formulation: UV Spectrophotometry and HPLC Validation. Jordan Journal of Pharmaceutical Sciences. 2024; 17(3): 468-80. DOI: https://doi.org/10.35516/jjps.v17i3.2359

Schwedhelm E, Maas R, Troost R, Böger RH. Clinical pharmacokinetics of antioxidants and their impact on systemic oxidative stress. Clinical pharmacokinetics. 2003; 42(5): 437-59. DOI: https://doi.org/10.2165/00003088-200342050-00003

Mertens-Talcott SU, Rios J, Jilma-Stohlawetz P, Pacheco-Palencia LA, Meibohm B, Talcott ST, et al. Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers. Journal of agricultural and food chemistry. 2008; 56(17): 7796-802. DOI: https://doi.org/10.1021/jf8007037

Wang S, Melnyk JP, Tsao R, Marcone MF. How natural dietary antioxidants in fruits, vegetables and legumes promote vascular health. Food Research International. 2011; 44(1): 14-22. DOI: https://doi.org/10.1016/j.foodres.2010.09.028

Bajes HR, Al-Dujaili EA. Polyphenolic-rich Fruits and Supplements Enhance Exercise Performance; General Review. Jordan Journal of Pharmaceutical Sciences. 2017; 10(3).

Davì G, Santilli F, Patrono C. Nutraceuticals in diabetes and metabolic syndrome. Cardiovascular Therapeutics. 2010; 28(4): 216-26. DOI: https://doi.org/10.1111/j.1755-5922.2010.00179.x

Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The metabolic syndrome. The lancet. 2010; 375(9710): 181-3. DOI: https://doi.org/10.1016/S0140-6736(09)61794-3

Hamed A, Al Zinati S, Al Swirky A. The effect of vitamin C alone or in combination with vitamin E on fasting blood glucose, glycosylated hemoglobin and lipid profile in type 2 diabetic patients (Gaza strip). Jordan Journal of Pharmaceutical Sciences. 2016; 9(1). DOI: https://doi.org/10.12816/0029864

Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annual review of nutrition. 2002; 22(1): 19-34. DOI: https://doi.org/10.1146/annurev.nutr.22.111401.144957

Tam K-W, Ho C-T, Tu S-H, Lee W-J, Huang C-S, Chen C-S, et al. α-Tocopherol succinate enhances pterostilbene anti-tumor activity in human breast cancer cells in vivo and in vitro. Oncotarget. 2018; 9(4): 4593. DOI: https://doi.org/10.18632/oncotarget.23390

Bouayed J, Bohn T. Exogenous antioxidants—double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxidative medicine and cellular longevity. 2010; 3(4): 228-37. DOI: https://doi.org/10.4161/oxim.3.4.12858

Lou D, Bao S-s, Li Y-h, Lin Q-m, Yang S-f, He J-y. Inhibitory Mechanisms of Myricetin on Human and Rat Liver Cytochrome P450 Enzymes. European journal of drug metabolism and pharmacokinetics. 2019: 1-8. DOI: https://doi.org/10.1007/s13318-019-00546-y

Kimura Y, Ito H, Ohnishi R, Hatano T. Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity. Food and Chemical Toxicology. 2010; 48(1): 429-35. DOI: https://doi.org/10.1016/j.fct.2009.10.041

Satoh T, Fujisawa H, Nakamura A, Takahashi N, Watanabe K. Inhibitory effects of eight green tea catechins on cytochrome P450 1A2, 2C9, 2D6, and 3A4 activities. Journal of Pharmacy & Pharmaceutical Sciences. 2016; 19(2): 188-97. DOI: https://doi.org/10.18433/J3MS5C