صياغة وتوصيف أقراص ميثيل دوبا العائمة باستخدام سواغات بوليمرزية: دراسة حول نظام توصيل الأدوية المضبوطة في الجهاز الهضمي
DOI:
https://doi.org/10.35516/jjps.v18i2.2718الكلمات المفتاحية:
ميثيل دوبا ، HPMC K 100 M، Carbopol 934، أقراص عائمة ، وقت تأخر عائمالملخص
يهدف هذا البحث إلى تطوير نظام جديد لتوصيل الأدوية للاحتفاظ بالجهاز الهضمي (GRDDS) يمكنه إطالة إفراز دواء ميثيل دوبا. في هذا البحث ، يتم تحضير الأقراص بطريقة الضغط المباشر باستخدام كاربابول 934 وبوليمر HPMC K100M ، باستخدام تقنية الفوار (للتركيبات F1 و F2 و F3 و F4) وغير الفوارة (F5). أحد الأدوية المستخدمة لعلاج ارتفاع ضغط الدم هو methyldopa ، وهو دواء ود يعمل مركزيا له عمر نصف قصير يبلغ 2 ساعة. التخدير, الغثيان, والقيء هي بعض الآثار الجانبية للدواء التي تحدث نتيجة لتكرار إعطائه (250 ملغ مرتين إلى ثلاث مرات في اليوم). لذلك ، سيكون من الأكثر فعالية تحضير GRDDS من methyldopa لإطلاق الدواء في بيئة المعدة لفترة طويلة. F3 هي دفعة التركيبة الأكثر فعالية لأن مزيج البوليمرات HPMC K 100M و carbopol 934 في أقراص ميثيل دوبا الفوارة يطيل بشكل كبير من إطلاق الدواء في 0.1N HCl.
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