السولفونات من الهيدروكسيكسانثون كعامل مضاد للسل: التوليف التسلسلي في خطوة واحدة، التحليل، والتقييم المبدئي باستخدام التفاعل الجزيئي
DOI:
https://doi.org/10.35516/jjps.v18i2.2850الكلمات المفتاحية:
هيدروكسيكسانثون، سولفوني، تفاعل جزيئي، مضاد للسلالملخص
تم تبسيط توليف المركبات السولفونية من الهيدروكسيكسانثون (4a و4b) إلى تسلسل واحد بهدف تقليل عدد الخطوات وزيادة الكفاءة. كما درست هذه الدراسة التفاعل الجزيئي لهذه المركبات المحضرة كعوامل محتملة ضد مرض السل. باستخدام برنامج AutoDock Vina، أظهرت نتائج التفاعل الجزيئي أن المركبات 4a و4b تظهر نشاطًا واعدًا ضد مرض السل من خلال ارتباطها الفعال بأنزيم DHPS. هذا الإنزيم، الذي يعد أمرًا حيويًا لنمو المتفطرة السلية، كان الهدف المحدد في الدراسة، مما يبرز قدرة المركبات على تثبيط DHPS وملاءمتها كأدوية مضادة للسل.
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