المكونات الكيميائية والتأثيرات الدوائية في المختبر/في الجسم الحي لزيت النعناع الفلفلي من نوع Mentha piperita L. في مناطق مختلفة من الجزائر
DOI:
https://doi.org/10.35516/jjps.v18i1.3069الكلمات المفتاحية:
مضاد للالتهابات، كروماتوغرافيا الغاز/مطياف الكتلة، الشفوية (أو الفصيلة الشفوية)، النعناع الفلفلي، الملف الكيميائي النباتي، الينالولالملخص
تتناول هذه الدراسة النعناع الفلفلي Mentha piperita L. المزروعة في منطقتين تتمتعان بمستويات بيئية مناخية مختلفة. الهدف هو تقييم ومقارنة الإنتاج والتركيب الكيميائي والأنشطة الدوائية للنبات في هذه الظروف البيئية المتنوعة . تم تحديد الملف الكيميائي النباتي لزيوت النعناع الفلفلي باستخدام تحليل الكروماتوغرافيا الغازية. تم إجراء الأنشطة الدوائية في المختبر وفي الجسم الحي باستخدام اختبارات مسكنة، ومضادة للالتهابات، ومضادة للبكتيريا، ومضادة للأكسدة. تم الحصول على أعلى إنتاجية من الزيت العطري من منطقة وادي سوف بنسبة 1.02%، بينما كان إنتاج منطقة الجزائر 0.86%. كشفت تحليلات GC/MS عن غنى الزيت العطري بالينالول وكذلك مشتقاته مثل أسيتات اليناليل في وادي سوف وبوتيرات اليناليل في الجزائر. في جميع الأنشطة الدوائية، كان زيت النعناع الفلفلي من منطقة وادي سوف أكثر فعالية بشكل ملحوظ من الزيت العطري من الجزائر. يمكن أن تساهم هذه الدراسة في تطبيق زيت النعناع الفلفلي في صناعة الأدوية كمصدر طبيعي واعد للمركبات المتطايرة ذات الخصائص العلاجية البارزة.
المراجع
El-Seedi H. R., Burman R., Mansour A., Turki Z., Boulos L., Gullbo J., Göransson U. The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: discovery of an active cardiac glycoside from Urginea maritima. J Ethnopharmacol. 2013; 145(3):746-757. DOI: https://doi.org/10.1016/j.jep.2012.12.007
Boucher H. W., Talbot G. H., Bradley J. S., Edwards J. E., Gilbert D., Rice L. B., Scheld M., Spellberg B., Bartlett J. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis. 2009; 48(1):1-12. DOI: https://doi.org/10.1086/595011
Hubert J., Berger M., Daydé J. Validation of a High‐performance Liquid Chromatography‐Ultraviolet Method to Quantify Soy Sapogenols A and B in Soy Germs from Different Cultivars and in Soy Isoflavone‐Enriched Supplements. J Food Sci. 2005; 70(8):c471-c477. DOI: https://doi.org/10.1111/j.1365-2621.2005.tb11503.x
Zahnit W., Smara O., Bechki L., Bensouici C., Messaoudi M., Benchikha N., Larkem I., Awuchi C. G., Sawicka B., Simal-Gandara J. Phytochemical profiling, mineral elements, and biological activities of Artemisia campestris L. grown in Algeria. Horticulturae. 2022; 8(10):914. DOI: https://doi.org/10.3390/horticulturae8100914
Sun J., Sun P., Kang C., Zhang L., Guo L., Kou Y. Chemical composition and biological activities of essential oils from six Lamiaceae folk medicinal plants. Front Plant Sci. 2022; 13:919294. DOI: https://doi.org/10.3389/fpls.2022.919294
Shrestha M., Sindhu K., Sah B. S., Jha P. K., Khaitu S., Pandey B., Yadav R. K., Gautam A., Yadav B. Hydroethanolic Leaf Extract of Murraya koenigii: Phytochemical Constituents and Biological Evaluation of its Toxicity and Antipyretic Activity in Wistar Albino Rats. Jordan Journal of Pharmaceutical Sciences. 2024; 17(4):811-817. DOI: https://doi.org/10.35516/jjps.v17i4.2532
Derwich E., Benziane Z., Boukir A. Chemical composition and in vitro antibacterial activity of the essential oil of Cedrus atlantica. Int J Agric Sci. 2010.
Guzmán E., Lucia A. Essential oils and their individual components in cosmetic products. Cosmetics. 2021; 8(4):114. DOI: https://doi.org/10.3390/cosmetics8040114
Godfrey E. O., Ejike O. O., Ojoniko A. W., Esther I. I., Faith O., Ugbedeojo A. A., Abdullahi B. I. Evaluating the Nutritional and Chemical Composition of Treculia Africana and Vigna Subterranea L. Seeds Collected from Kogi State, Nigeria. Jordan Journal of Pharmaceutical Sciences. 2024; 17(4):767-782. DOI: https://doi.org/10.35516/jjps.v17i4.2480
Yadegarinia D., Gachkar L., Rezaei M. B., Taghizadeh M., Astaneh S. A., Rasooli I. Biochemical activities of Iranian Mentha piperita L. and Myrtus communis L. essential oils. Phytochemistry. 2006; 67(12):1249-1255. DOI: https://doi.org/10.1016/j.phytochem.2006.04.025
Tafrihi M., Imran M., Tufail T., Gondal T. A., Caruso G., Sharma S., Sharma R., Atanassova M., Atanassov L., Tsouh Fokou P. V. The wonderful activities of the genus Mentha: Not only antioxidant properties. Molecules. 2021; 26(4):1118. DOI: https://doi.org/10.3390/molecules26041118
Abu-Darwish D., Shibli R., Al-Abdallat A. M. Phenolic Compounds and Antioxidant Activity of Chiliadenus montanus (Vhal.) Brullo. grown in vitro. Jordan Journal of Pharmaceutical Sciences. 2024; 17(3):611-628. DOI: https://doi.org/10.35516/jjps.v17i3.2248
Jean B. Pharmacognosie, phytochimie, plantes médicinales (4e éd.). Lavoisier. 2009.
Kalemba D., Synowiec A. Agrobiological interactions of essential oils of two menthol mints: Mentha piperita and Mentha arvensis. Molecules. 2019; 25(1):59. DOI: https://doi.org/10.3390/molecules25010059
Kizil S., Hasimi N., Tolan V., Kilinc E., Yuksel U. Mineral content, essential oil components and biological activity of two Mentha species (M. piperita L., M. spicata L.). Turk J Field Crops. 2010; 15(2):148-153.
Quézel P., Santa S. Nouvelle flore de l'Algérie et des régions désertiques méridionales. 1962.
Zerrouk S., Seijo M. C., Boughediri L., Escuredo O., Rodríguez-Flores M. S. Palynological characterisation of Algerian honeys according to their geographical and botanical origin. Grana. 2014; 53(2):147-158. DOI: https://doi.org/10.1080/00173134.2014.897751
Bauer A., Kirby W., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966; 45(4_ts):493-496. DOI: https://doi.org/10.1093/ajcp/45.4_ts.493
Del Castillo M. R., Blanch G. P., Herraiz M. Natural variability of the enantiomeric composition of bioactive chiral terpenes in Mentha piperita. J Chromatogr A. 2004; 1054(1-2):87-93. DOI: https://doi.org/10.1016/j.chroma.2004.08.055
Staniszewska M., Kula J., Wieczorkiewicz M., Kusewicz D. Essential oils of wild and cultivated carrots—the chemical composition and antimicrobial activity. J Essent Oil Res. 2005; 17(5):579-583. DOI: https://doi.org/10.1080/10412905.2005.9699002
Boudjema K., Guerdouba A., Hali L. Composition, physicochemical analysis, antimicrobial and anti-inflammatory activities of the essential oils obtained from Ruta chalepensis L. growing wild in northern Algeria. J Chem Soc Pak. 2018; 40(6):1054-.
Sacchetti G., Maietti S., Muzzoli M., Scaglianti M., Manfredini S., Radice M., Bruni R. Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods. Food Chem. 2005; 91(4):621-632. DOI: https://doi.org/10.1016/j.foodchem.2004.06.031
Franzin L., Pennazio M., Cabodi D., Rossini F. P., Gioannini P. Clarithromycin and amoxicillin susceptibility of Helicobacter pylori strains isolated from adult patients with gastric or duodenal ulcer in Italy. Curr Microbiol. 2000; 40:96-100. DOI: https://doi.org/10.1007/s002849910018
Ponce A., Fritz R., Del Valle C., Roura S. Antimicrobial activity of essential oils on the native microflora of organic Swiss chard. LWT - Food Sci Technol. 2003; 36(7):679-684. DOI: https://doi.org/10.1016/S0023-6438(03)00088-4
Lambert R., Skandamis P. N., Coote P. J., Nychas G. J. A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. J Appl Microbiol. 2001; 91(3):453-462. DOI: https://doi.org/10.1046/j.1365-2672.2001.01428.x
European-Council. European Pharmacopoeia 2007.
Singh R., Shushni M. A., Belkheir A. Antibacterial and antioxidant activities of Mentha piperita L. Arab J Chem. 2015; 8(3):322-328. DOI: https://doi.org/10.1016/j.arabjc.2011.01.019
Benmouloud A., Zatra Y., Belkadi A., Halli L., Kacimi L., Souames S., Aknoun-Sail N. Evaluation of gastroprotective effect of jujube honey in ethanol-induced stomach ulcer in mice. Indian J Tradit Knowl. 2023; 22(1):150-159. DOI: https://doi.org/10.56042/ijtk.v22i1.33680
Vogel H. G. Drug discovery and evaluation: pharmacological assays. Springer Science & Business Media. 2002.
Levy L. Carrageenan paw edema in the mouse. Lif Sci. 1969; 8(11):601-606. DOI: https://doi.org/10.1016/0024-3205(69)90021-6
Bruneton J. Pharmacognosie, phytochimie, plantes médicinales (Lavoisier ed.). Tec et Doc édition. 1999.
Degnon G., Adjou E., Metome G., Dahouenon-Ahoussi E. Efficacy of essential oils of Cymbopogon citratus and Mentha piperita in stabilizing the fresh cow's milk in southern Benin. 2016.
Myadelets M., Domrachev D., Cheremushkina V. A study of the chemical composition of essential oils of some species from the Lamiaceae L. family cultivated in the Western Siberian Region. RUSS J BIOORG. 2013; 39:733-738. DOI: https://doi.org/10.1134/S1068162013070091
Dwivedi S., Khan M., Srivastava S. K., Syamasunnder K., Srivastava A. Essential oil composition of different accessions of Mentha × piperita L. grown on the northern plains of India. Flavour Fragr J. 2004; 19(5):437-440. DOI: https://doi.org/10.1002/ffj.1333
Maffei M., Mucciarelli M. Essential oil yield in peppermint/soybean strip intercropping. Field Crops Res. 2003; 84(3):229-240. DOI: https://doi.org/10.1016/S0378-4290(03)00092-3
Debbab A., Mosaddak B., Aly A., Hakiki A., Mosaddak M. Chemical characterization and toxicological evaluation of the essential oil of Mentha piperita L. growing in Morocco. Sci Stu Res. 2007; 8(3):281-288.
Saharkhiz M. J., Motamedi M., Zomorodian K., Pakshir K., Miri R., Hemyari K. Chemical composition, antifungal and antibiofilm activities of the essential oil of Mentha piperita L. Int Sch Res Notices. 2012; 2012. DOI: https://doi.org/10.5402/2012/718645
Verma R., Rahman L., Verma R., Chauhan A., Yadav A., Singh A. Essential oil composition of menthol mint (Mentha arvensis) and peppermint (Mentha piperita) cultivars at different stages of plant growth from Kumaon region of Western Himalaya. Open Access J Med Aromat Plants. 2010; 1(1):13-18. DOI: https://doi.org/10.1080/0972060X.2010.10643799
Liu W., Yin D., Li N., Hou X., Wang D., Li D., Liu J. Influence of environmental factors on the active substance production and antioxidant activity in Potentilla fruticosa L. and its quality assessment. Sci Rep. 2016; 6(1):28591. DOI: https://doi.org/10.1038/srep28591
Chifundera K. B., Kizungub M. Phytochemical screening and antibacterial testing of Ficus sycomorus extracts. Communication shorts. Fitoterapia. 2016; 535-539.
Harchaoui L., Ouafi S., Chabane D. UPLC-MS profiling, antimicrobial and antipyretic activities of Deverra scoparia Coss. & Dur. extracts. Indian J Tradit Knowl. 2022; 21(1):40-47. DOI: https://doi.org/10.56042/ijtk.v21i1.28405
Carson C. F., Mee B. J., Riley T. V. Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy. ANTIMICROB AGENTS CH. 2002; 46(6):1914-1920. DOI: https://doi.org/10.1128/AAC.46.6.1914-1920.2002
Jusoh S., Sirat H. M., Ahmad F., Basar N., Bakar M. B., Jamil S., Haron S. Essential oils of leaves and pseudo stems Alpinia malaccensis and antimicrobial activities. J Phys Conf Ser. 2020; 1529(4):042050.
Meincken M., Holroyd D., Rautenbach M. Atomic force microscopy study of the effect of antimicrobial peptides on the cell envelope of Escherichia coli. Antimicrob Agents Chemother. 2005; 49(10):4085-4092.
Dorman H. D., Deans S. G. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. 2000; 88(2):308-316.
Desam N. R., Al-Rajab A. J., Sharma M., Mylabathula M. M., Gowkanapalli R. R., Albratty M. Chemical constituents, in vitro antibacterial and antifungal activity of Mentha × Piperita L. (peppermint) essential oils. J King Saud Univ Sci. 2019; 31(4):528-533.
Ruberto G., Baratta M. T. Antioxidant activity of selected essential oil components in two lipid model systems. Food Chem. 2000; 69(2):167-174.
Gharib F., da Silva J. T. Composition, total phenolic content and antioxidant activity of the essential oil of four Lamiaceae herbs. Med Aromat Plant Sci Biotechnol. 2013; 7(1):19-27.
Jusoh S., Sirat H. M., Ahmad F., Basar N., Bakar M. B., Jamil S., Haron S. Essential oils of leaves and pseudo stems Alpinia malaccensis and antimicrobial activities. J Phys Conf Ser. 2020; 1529(4):042050. DOI: https://doi.org/10.1088/1742-6596/1529/4/042050
Meincken M., Holroyd D., Rautenbach M. Atomic force microscopy study of the effect of antimicrobial peptides on the cell envelope of Escherichia coli. Antimicrob Agents Chemother. 2005; 49(10):4085-4092. DOI: https://doi.org/10.1128/AAC.49.10.4085-4092.2005
Dorman H. D., Deans S. G. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. 2000; 88(2):308-316. DOI: https://doi.org/10.1046/j.1365-2672.2000.00969.x
Desam N. R., Al-Rajab A. J., Sharma M., Mylabathula M. M., Gowkanapalli R. R., Albratty M. Chemical constituents, in vitro antibacterial and antifungal activity of Mentha × Piperita L. (peppermint) essential oils. J King Saud Univ Sci. 2019; 31(4):528-533. DOI: https://doi.org/10.1016/j.jksus.2017.07.013
Ruberto G., Baratta M. T. Antioxidant activity of selected essential oil components in two lipid model systems. Food Chem. 2000; 69(2):167-174. DOI: https://doi.org/10.1016/S0308-8146(99)00247-2
Gharib F., da Silva J. T. Composition, total phenolic content and antioxidant activity of the essential oil of four Lamiaceae herbs. Med Aromat Plant Sci Biotechnol. 2013; 7(1):19-27.







