جسيمات نانوية من الفيبروين معدلة ببولي إيثيلين إيمين لإطلاق خاضع للتحكم كوسيلة محتملة للتوصيل الفموي للكويرسيتين
DOI:
https://doi.org/10.35516/jjps.v18i3.3082الكلمات المفتاحية:
الفيبروين، بولي إيثيلين إيمين، الجسيمات النانوية، الكويرسيتين، التوصيل الفمويالملخص
تُعد المركبات متعددة الفينول فئة كبيرة من المركبات الكيميائية المستخدمة في تطبيقات طبية حيوية متنوعة. ومع ذلك، فإن هذه المركبات عرضة للتدهور، لا سيما ضمن بيئات الأس الهيدروجيني المتباينة في الجهاز الهضمي، مما يعيق استخدامها في الإعطاء الفموي. لذلك، يهدف هذا العمل إلى تطوير جسيمات نانوية من الفيبروين (( FNP) وجسيمات فيبروين معدلة ببولي إيثيلين إيمين (PEI-FNP) لحماية وتوصيل الكويرسيتين (QC) )فمويًا، باعتباره نموذجًا للمركبات متعددة الفينول. تم تحضير الجسيمات باستخدام طريقتين مختلفتين: الامتزاز والتكثيف المشترك. أظهرت الصيغتان خصائص فيزيائية-كيميائية مناسبة للإعطاء الفموي، بما في ذلك أحجام نانوية (حوالي 700 نانومتر لـ FNP-QC وحوالي 200 نانومتر لـ PEI-FNP-QC)، توزيع حجمي ضيق (مؤشر تعددية التشتت < 0.3)، إمكانات زيتا قابلة للتعديل (حوالي -20 مللي فولت لـ FNP-QC وحوالي +25 مللي فولت لـ PEI-FNP-QC)، زيادة ذوبانية الكويرسيتين في الماء بمقدار 2-3 مرات، وتفاعلات كيميائية ملحوظة (روابط هيدروجينية وتفاعلات أيونية) بين QC والفيبروين/PEI. علاوة على ذلك، وبناءً على عملية التحضير وتركيب الجسيمات، أظهرت الجسيمات كفاءات احتواء معتدلة للكويرسيتين (35–75%)، وأسـطحًا ناعمة أو خشنة، وامتصاصًا سريعًا للدواء يتبع نماذج تشمل متساوي حرارة لانغموير ودوبينين-رادوشكيفيتش، بالإضافة إلى حركية من الدرجة الثانية الزائفة. المثير للاهتمام أن الجسيمات، في بيئة فموية محاكية، تمكنت من حماية QC في الظروف المعدية عند pH 1.2، مع إطلاق أقل من 20%، مع استمرار إطلاقه في الأمعاء عند pH 6.8، بمعدلات يمكن التحكم بها من خلال تعديل طرق التحضير و/أو وظيفة PEI. خلاصة القول، أظهرت كل من FNP وPEI-FNP إمكانات كبيرة كنظم توصيل دوائية خاضعة للتحكم للإعطاء الفموي للمركبات متعددة الفينول.
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التنزيلات
منشور
كيفية الاقتباس
إصدار
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