العلاقة بين مستويات الزّنك والنّحاس ومقاومة الأنسولين لدى مريضات متلازمة المبيض متعدّد الكيسات في مدينة حمص
DOI:
https://doi.org/10.35516/jjps.v17i2.1787الكلمات المفتاحية:
متلازمة المبيض متعدّد الكيسات، الزّنك، النّحاس، مقاومة الأنسولينالملخص
الهدف: دراسة العلاقة بين مستويات الزّنك والنّحاس ومقاومة الأنسولين الّتي هي الآليّة الإمراضيّة الرّئيسيّة لمتلازمة المبيض متعدّد الكيسات (PCOS)، ومقارنة مستويات المعادن مع الأشخاص الأصحّاء في حمص.
طريقة العمل: شمل البحث 63 مريضة تم تشخيصهن حديثاً بمتلازمة المبيض متعدّد الكيسات، وقبل أن تتم معالجتهن في مستشفى الباسل في حمص، سوريا، إلى جانب 25 امرأة سليمة من نفس العمر. تمَّ الحصول على عيّنات الدّم باستخدام الأنابيب الجافّة للقيام بمقايسة مستويات الزّنك والنّحاس والغلوكوز وهرمون الأنسولين. وفي وقت لاحق، تم حساب المؤشّرات التّالية HOMA-IR وQUICK.
النّتائج: في مجموعة المريضات، كانت مستويات الزّنك في الدّم أقل بشكل ملحوظ ((p = 0.000، وكانت مستويات النّحاس في الدّم أعلى بشكل ملحوظ ((p = 0.000 مقارنة بالأشخاص الأصحّاء. في المريضات الّلواتي تعانين من مقاومة الأنسولين، كانت مستويات الزّنك في الدّم أقل بشكل ملحوظ (p = 0.004)، وكانت مستويات النّحاس في الدّم أعلى بشكل ملحوظ (p = 0.000) مقارنة بالمريضات الّلواتي لا تعانين من مقاومة الأنسولين. في المريضات الّلواتي لا تعانين من مقاومة الأنسولين مقارنة بالنّساء السّليمات، كانت مستويات الزّنك في الدّم أقل بشكل ملحوظ (p = 0.000)، وكانت مستويات النّحاس في الدّم أعلى بشكل ملحوظ (p = 0.000). وُجِد ارتباط إيجابي بين النّحاس وHOMA-IR (r=0.572**) p=0.000))، وارتباط سلبي بين الزّنك وHOMA-IR (r=-0.865**) (p=0.000).
الخلاصة: إنَّ خلل مستويات الزّنك والنّحاس له آثار على تطوّر متلازمة المبيض متعدّد الكيسات، سواء ترافقت مع مقاومة الأنسولين أو تواجدت بشكل مستقل عنها.
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