The Relationship between Levels of Zinc and Copper and Insulin Resistance in Polycystic Ovary Syndrome Patients in Homs
DOI:
https://doi.org/10.35516/jjps.v17i2.1787Keywords:
Sulaf Alwassouf , Polycystic ovary syndrome, Zinc, Copper, Insulin resistanceAbstract
Objective: To investigate the association between zinc and copper levels and insulin resistance, a key pathological mechanism of Polycystic Ovary Syndrome (PCOS), and to compare these levels with those of healthy subjects in Homs.
Methods: The study included 63 female patients newly diagnosed with PCOS, prior to treatment at Al-Basil Hospital in Homs, Syria, along with 25 healthy subjects of similar age. Blood samples were collected using dry tubes for laboratory measurements of zinc, copper, glucose, and insulin hormone levels. Subsequently, the HOMA-IR and QUICKI indices were calculated.
Results: In the patients' group, serum zinc levels were significantly lower (p-value=0.000), and serum copper levels were significantly higher (p-value=0.000) compared to healthy subjects. Among patients with insulin resistance, serum zinc levels were significantly lower (p-value=0.004), and serum copper levels were significantly higher (p-value=0.000) compared to patients without insulin resistance. Patients without insulin resistance had significantly lower serum zinc levels (p-value=0.000) and significantly higher serum copper levels (p-value=0.000) compared to healthy subjects. There was a positive correlation between copper and HOMA-IR (r=0.572**, p-value=0.000), and a negative correlation between zinc and HOMA-IR (r=-0.865**, p-value=0.000).
Conclusion: The imbalance in zinc and copper levels appears to play a role in the development of PCOS, both in relation to insulin resistance and potentially as an independent factor.
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