Role of Biochemical and Inflammatory Markers in Monitoring of Covid-19 Patients Vaccinated by Pfizer-BioNTech in Kirkuk City/Iraq
DOI:
https://doi.org/10.35516/jmj.v59i5.2274الكلمات المفتاحية:
Covid-19، Pfizer-BioNTech vaccine، biomarkers، Kirkukالملخص
The coronavirus disease 2019 (COVID-19) pandemic has killed millions of people and infected millions more. Thus, there was an urgent worldwide need for the scientific community to create vaccines. A retrospective observational study was performed in Azadi teaching hospital from the period of June 2020 to December 2021 on 250 patients (106 female and 144 male patients). The cases were followed up at two different time points, firstly before receiving the vaccine, then after receiving two doses of the vaccine. Lactate dehydrogenase (LDH) enzyme, D-Dimer, CRP, S. Ferritin, S. Creatinine B. Urea and Lymphocyte %, were measured for all patients enrolled in the study before and after vaccination. The concentration levels of B. Urea, S. Creatinine, LDH, D-Dimer, S. Ferritin, and CRP were lower post vaccination. Lymphocyte percentage exhibited the highest concentration levels post vaccination. There were significant differences (P< 0.05) between the concentration levels of all the biomarkers pre and post vaccination with the exception of the concentration levels of S. Creatinine, and B. Urea that showed non-significant variances after vaccination. These results were true for both male and female patients. In conclusions Pfizer-BioNTech vaccines have a significant role in down regulating of some inflammatory biomarkers such as: LDH, D-Dimer, S. Ferritin, and CRP and upregulating of lymphocyte percentage. Generally, the vaccine has an insignificant impact on renal function tests in both male and female patients. The Pfizer- BioNTech COVID-19 vaccine might prompt mild side effects after the first and/or second shot.
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