Automated Detection of Retinal Diseases Using Artificial Intelligence-Enhanced Ocular Coherence Tomography Imaging: Bibliometric Analysis

المؤلفون

  • Alaa Tarazi School of Medicine, The University of Jordan, Amman, Jordan
  • Yazan AlSawaftah School of Medicine, The University of Jordan, Amman, Jordan
  • Omar Basheti School of Medicine, The University of Jordan, Amman, Jordan.
  • Nakhleh Abu-Yaghi Department of Special Surgery, Ophthalmology Division, School of Medicine, The University of Jordan, Amman, Jordan

DOI:

https://doi.org/10.35516/jmj.v59i3.4064

الكلمات المفتاحية:

Artificial Intelligence، Optical Coherence Tomography، Retinal Diseases، Deep Learning، Diabetic Retinopathy

الملخص

Artificial intelligence (AI) has revolutionized optical coherence tomography (OCT) imaging for the better detection of retinal diseases like diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. Here, bibliometric analysis of AI in OCT is presented. We conducted a systematic search in the Web of Science Core Collection (WoSCC) database up to January 22, 2025 with the help of AI and OCT-related terms. The journal articles and reviews on the topic were examined based on publication trends, author productivity, institution affiliation, and keyword co-occurrence. Visualization was performed through VOSviewer software (1.6.20). A total of 765 articles were analyzed with an increasing trend in publications, led by the USA (30.7%), China (23.3%), and the UK (11.1%) in research production. The most cited institution was the Medical University of Vienna (9.0%), and the most productive journal was Scientific Reports (7.3%). The most common keywords were "Optical Coherence Tomography", "Deep Learning", and "Diabetic Retinopathy" with frequency of 469, 297, 221, respectively. Our review of AI-enhanced OCT for retinal diseases was both comprehensive and systematic, identifying key trends and current research hotspots. As research productivity in this field continues to grow, the focus is increasingly shifting toward developing more accurate AI-driven imaging techniques to improve the diagnosis of various retinal diseases. Future work should prioritize algorithm validation and clinical implementation to facilitate widespread adoption

المراجع

Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science. 1991; 254: 1178-1181.

Spaide RF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G. Optical coherence tomography angiography. Prog Retin Eye Res. 2018; 64: 1-55.

Wang RY, Zhu SY, Hu XY, Sun L, Zhang SC, Yang WH. Artificial intelligence applications in ophthalmic optical coherence tomography: a 12-year bibliometric analysis. Int J Ophthalmol. 2024; 17: 2295-2307.

Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol. 2009; 147: 811-815.

Kashani AH, Chen CL, Gahm JK, et al. Optical coherence tomography angiography: a comprehensive review of current methods and clinical applications. Prog Retin Eye Res. 2017; 60: 66-100.

De Fauw J, Ledsam JR, Romera-Paredes B, et al. Clinically applicable deep learning for diagnosis and referral in retinal disease. Nat Med. 2018; 24: 1342-1350.

Gulshan V, Peng L, Coram M, et al. Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA. 2016; 316: 2402-2410.

Ting DSW, Cheung CY, Lim G, et al. Artificial intelligence and deep learning in ophthalmology. Br J Ophthalmol. 2019; 103: 167-175.

Abramoff MD, Lavin PT, Birch M, Shah N, Folk JC. Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices. NPJ Digit Med. 2018; 1: 39.

Lee SC, Rusakevich AM, Amin A, et al. Long-term retinal vascular changes in age-related macular degeneration measured using optical coherence tomography angiography. Ophthalmic Surg Lasers Imaging Retina. 2022; 53: 529-536.

Venhuizen FG, van Ginneken B, Liefers B, et al. Deep learning approach for the detection and quantification of intraretinal cystoid fluid in multivendor optical coherence tomography. Biomed Opt Express. 2018; 9: 1545-1569.

Liu PR, Lu L, Zhang JY, et al. Application of deep learning-based image analysis in ophthalmology: a systematic review. Clin Exp Ophthalmol. 2023; 51: 446-460.

Christopher M, Belghith A, Bowd C, et al. Performance of deep learning architectures and transfer learning for detecting glaucomatous optic neuropathy in fundus photographs. Sci Rep. 2018; 8: 16685.

Srinivasan PP, Kim LA, Mettu PS, et al. Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images. Biomed Opt Express. 2014; 5: 3566-3577.

Kermany DS, Goldbaum M, Cai W, et al. Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell. 2018; 172: 1122-1131.

van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010; 84: 523-538.

Kirby A. Exploratory bibliometrics: Using VOSviewer as a preliminary research tool. Publications. 2023; 11: 10.

Yang J, Wu S, Dai R, Yu W, Chen Y. Publication trends of artificial intelligence in retina in 10 years: Where do we stand? Front Med (Lausanne). 2022; 9: 1001673.

Aresta G, Araújo T, Fazekas B, et al. Interactive deep learning-based retinal OCT layer segmentation refinement by regressing translation maps. IEEE Access. 2024; 12: 47009-47023.

Coulibaly LM, Riedl R, Glatz W, et al. Repeatability of microperimetry in areas of retinal pigment epithelium and photoreceptor loss in geographic atrophy supported by artificial intelligence–based optical coherence tomography biomarker quantification. Am J Ophthalmol. 2024; 271: 347-359.

Coulibaly LM, Riedl R, Glatz W, et al. Repeatability of microperimetry in areas of retinal pigment epithelium and photoreceptor loss in geographic atrophy supported by artificial intelligence–based optical coherence tomography biomarker quantification. Am J Ophthalmol. 2024; 271: 347-359.

Glatz M, Riedl R, Glatz W, et al. Blindness and visual impairment in Central Europe. PLoS One. 2022; 17: e0261897.

Zhao J, Lu Y, Qian Y, Luo Y, Yang W. Emerging trends and research foci in artificial intelligence for retinal diseases: bibliometric and visualization study. J Med Internet Res. 2022; 24: e37532.

Pinto-Coelho L. How artificial intelligence is shaping medical imaging technology: a survey of innovations and applications. Bioengineering (Basel). 2023; 10: 1435.

Yao J, Lim J, Lim GYS, et al. Novel artificial intelligence algorithms for diabetic retinopathy and diabetic macular edema. Eye Vis. 2024; 11: 23.

Romero-Aroca P. Managing diabetic macular edema: the leading cause of diabetes blindness. World J Diabetes. 2011; 2: 98-104.

Xu X, Zhang M, Huang S, et al. The application of artificial intelligence in diabetic retinopathy: progress and prospects. Front Cell Dev Biol. 2024; 12: 1473176.

Tonti E, Tonti S, Mancini F, et al. Artificial intelligence and advanced technology in glaucoma: a review. J Pers Med. 2024; 14: 1062.

Vision Loss Expert Group of the Global Burden of Disease Study. Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 2000 to 2020. Eye. 2024; 38: 2047-2057.

Bourne RRA, Flaxman SR, Braithwaite T, et al. Causes of vision loss worldwide, 1990–2010: a systematic analysis. Lancet Glob Health. 2013; 1: e339-e349.

Upadhyay T, Prasad R, Mathurkar S. A narrative review of the advances in screening methods for diabetic retinopathy: enhancing early detection and vision preservation. Cureus. 2024; 16: e53586.

Fatima M, Pachauri P, Akram W, Parvez M, Ahmad S, Yahya Z, Enhancing retinal disease diagnosis through AI: Evaluating performance, ethical considerations, and clinical implementation. Informatics and Health. 2024; 1; 57-69

Phan LT, Broadhead GK, Hong TH, Chang AA. Predictors of visual acuity after treatment of neovascular age-related macular degeneration—current perspectives. Clin Ophthalmol. 2021; 15: 3351-3367.

Ayoub T, Patel N. Age-related macular degeneration. J R Soc Med. 2009; 102: 56-61.

Ferrara N, Damico L, Shams N, Lowman H, Kim R. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina. 2006; 26: 859-870.

Hang A, Feldman S, Amin AP, Ochoa JAR, Park SS. Intravitreal Anti-Vascular Endothelial Growth Factor Therapies for Retinal Disorders. Pharmacol 2023; 16(8): 1140.

Wykoff CC, Clark WL, Nielsen JS, et al. Optimizing anti-VEGF treatment outcomes for patients with neovascular age-related macular degeneration. J Manag Care Spec Pharm. 2018; 24: S3-S15.

Schmidt-Erfurth U, Klimscha S, Waldstein S, et al. A view of the current and future role of optical coherence tomography in the management of age-related macular degeneration. Eye. 2017; 31: 26-44.

Bakri SJ, Bektas M, Sharp D, Luo R, Sarda SP, Khan S. Geographic atrophy: Mechanism of disease, pathophysiology, and role of the complement system. J Manag Care Spec Pharm 2023; 29(5-a Suppl): S2-S11.

Elsharkawy M, Elrazzaz M, Ghazal M, et al. Role of Optical Coherence Tomography Imaging in Predicting Progression of Age-Related Macular Disease: A Survey. Diagnostics (Basel) 2021; 11(12): 2313.

Balaratnasingam C, An D, Hein M, Yu P, Yu DY. Studies of the retinal microcirculation using human donor eyes and high-resolution clinical imaging: Insights gained to guide future research in diabetic retinopathy. Prog Retin Eye Res 2023; 94: 101134.

Mak BD, Djulbegovic H, Bair H, Taylor Gonzalez DJ, Ishikawa H, Wollstein G, Schuman JS. Artificial Intelligence for Optical Coherence Tomography in Glaucoma. Trans Vis Sci Tech 2025; 14(1): 27.

Olawade DB, Weerasinghe K, Mathugamage MDDE, Odetayo A, Aderinto N, Teke J, Boussios S. Enhancing Ophthalmic Diagnosis and Treatment with Artificial Intelligence. Medicina 2025; 61(3): 433.

التنزيلات

منشور

2025-09-08

كيفية الاقتباس

Tarazi, A., AlSawaftah, Y. ., Basheti, O. ., & Abu-Yaghi, N. (2025). Automated Detection of Retinal Diseases Using Artificial Intelligence-Enhanced Ocular Coherence Tomography Imaging: Bibliometric Analysis . المجلة الطبية الأردنية, 59(4). https://doi.org/10.35516/jmj.v59i3.4064

إصدار

القسم

Articles