الفايتوزومات: منصة متطورة لتوصيل المواد الكيميائية النباتية من خلال تعزيز التوافر البيولوجي

Barani M., Sangiovanni E. and Angarano M. Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature. Int J Nanomedicine. 2021; 16: 6983-7022. DOI: https://doi.org/10.2147/IJN.S318416

Jadhav N., Nadaf S., Lohar D., Ghagare P. and Powar T. Phytochemicals Formulated as Nanoparticles: Inventions, Recent Patents and Future Prospects. Recent Pat Drug Deliv Formul. 2017; 11(3): 173-186. DOI: https://doi.org/10.2174/1872211311666171120102531

Shriram R., Moin A., Alotaibi H., et al. Phytosomes as a Plausible Nano-Delivery System for Enhanced Oral Bioavailability and Improved Hepatoprotective Activity of Silymarin. Pharmaceuticals (Basel). 2022; 15(7): 790. DOI: https://doi.org/10.3390/ph15070790

Nuchuchua O., Inpan R., Srinuanchai W., et al. Phytosome Supplements for Delivering Gymnema inodorum Phytonutrients to Prevent Inflammation in Macrophages and Insulin Resistance in Adipocytes. Foods. 2023; 12(11): 2257.

Semalty A., Semalty M., Rawat M., Franceschi F. Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals. Fitoterapia. 2010; 81(5): 306-314. DOI: https://doi.org/10.1016/j.fitote.2009.11.001

Gaikwad S., Morade Y., Kothule A., Kshirsagar S., Laddha U. and Salunkhe K. Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook. Heliyon. 2023; 9(6): e16561. DOI: https://doi.org/10.1016/j.heliyon.2023.e16561

Bibi Z. and Jahan N. Synthesis and biological evaluation of Ellettaria cardamomum (Cardamom) Phytosomes. Pak J Pharm Sci. 2020; 33(5): 2121-2129.

Islam N., Irfan M., Hussain T., et al. Piperine phytosomes for bioavailability enhancement of domperidone. J Liposome Res. 2022; 32(2): 172-180. DOI: https://doi.org/10.1080/08982104.2021.1918153

Mirzaei H., Shakeri A., Rashidi B., Jalili A., Banikazemi Z. and Sahebkar A. Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother. 2017; 85: 102-112. DOI: https://doi.org/10.1016/j.biopha.2016.11.098

Pandey R., Bhairam M., Shukla S. and Gidwani B. Colloidal and vesicular delivery system for herbal bioactive constituents. Daru. 2021; 29(2): 415-438. DOI: https://doi.org/10.1007/s40199-021-00403-x

Teja P., Mithiya J., Kate A., Bairwa K. and Chauthe S. Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview. Phytomedicine. 2022; 96: 153890. DOI: https://doi.org/10.1016/j.phymed.2021.153890

Chouhan N., Mittal V., Kaushik D., Khatkar A. and Raina M. Self-emulsifying drug delivery system (SEDDS) for phytoconstituents: a review. Curr Drug Deliv. 2015; 12(2): 244-253. DOI: https://doi.org/10.2174/1567201811666141021142606

Rahman M., Beg S., Verma A., et al. Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery. J Pharm Pharmacol. 2017; 69(1): 1-14. DOI: https://doi.org/10.1111/jphp.12661

Kesarwani K., Gupta R. and Mukerjee A. Bioavailability enhancers of herbal origin: an overview. Asian Pac J Trop Biomed. 2013; 3(4): 253-266. DOI: https://doi.org/10.1016/S2221-1691(13)60060-X

Mahomoodally M., Sadeer N., Edoo M. and Venugopala K.N. The Potential Application of Novel Drug Delivery Systems for Phytopharmaceuticals and Natural Extracts - Current Status and Future Perspectives. Mini Rev Med Chem. 2021; 21(18): 2731-2746. DOI: https://doi.org/10.2174/1389557520666200730160911

Saraf S., Gupta A., Alexander A., Khan J., Jangde M. and Saraf S. Advancements and Avenues in Nanophytomedicines for Better Pharmacological Responses. J Nanosci Nanotechnol. 2015; 15(6): 4070-4079. DOI: https://doi.org/10.1166/jnn.2015.10333

Alkholifi F., Alam A., Foudah A. I., and Yusufoglu H. S. Phospholipid-Based Topical Nano-Hydrogel of Mangiferin: Enhanced Topical Delivery and Improved Dermatokinetics. Gels (Basel, Switzerland). 2023; 9(3): 178. DOI: https://doi.org/10.3390/gels9030178

Jahangir M., Anand C., Muheem A., et al. Nano Phytomedicine Based Delivery System for CNS Disease. Curr Drug Metab. 2020; 21(9): 661-673. DOI: https://doi.org/10.2174/1389200221666200523161003

Mughees M. and Wajid S. Herbal Based Polymeric Nanoparticles as a Therapeutic Remedy for Breast Cancer. Anticancer Agents Med Chem. 2021; 21(4): 433-444. DOI: https://doi.org/10.2174/1871520620666200619171616

Abu Dayyih W., Hailat M., Albtoush S., Albtoush E., Abu Dayah A., Alabbadi I., and Hamad M. F. Nanomedicine Advancements in Cancer Therapy: A Scientific Review. Jordan Journal of Pharmaceutical Sciences. 2024; 17(3), 506–529. DOI: https://doi.org/10.35516/jjps.v17i3.2384

Ben-Shabat S., Yarmolinsky L., Porat D. and Dahan A. Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies. Drug Deliv Transl Res. 2020; 10(2): 354-367. DOI: https://doi.org/10.1007/s13346-019-00691-6

Mohapatra D., Agrawal A. and Sahu A. Exploring the potential of solid dispersion for improving solubility, dissolution & bioavailability of herbal extracts, enriched fractions, and bioactives. J Microencapsul. 2021; 38(7-8): 594-612. DOI: https://doi.org/10.1080/02652048.2021.1963342

Barkat M., Goyal A., Barkat H., Salauddin M., Pottoo F. and Anwer E. Herbal Medicine: Clinical Perspective and Regulatory Status. Comb Chem High Throughput Screen. 2021; 24(10): 1573-1582. DOI: https://doi.org/10.2174/1386207323999201110192942

Nuchuchua O., Inpan R., Srinuanchai W., et al. Phytosome Supplements for Delivering Gymnema inodorum Phytonutrients to Prevent Inflammation in Macrophages and Insulin Resistance in Adipocytes. Foods. 2023; 12(11): 2257. DOI: https://doi.org/10.3390/foods12112257

Yadav N., Parveen S. and Banerjee M. Potential of nano-phytochemicals in cervical cancer therapy. Clin Chim Acta. 2020; 505: 60-72. DOI: https://doi.org/10.1016/j.cca.2020.01.035

Chen R., Chavda V., Patel A. and Chen Z. Phytochemical Delivery Through Transferosome (Phytosome): An Advanced Transdermal Drug Delivery for Complementary Medicines. Front Pharmacol. 2022; 13: 850-862. DOI: https://doi.org/10.3389/fphar.2022.850862

Rathee S. and Kamboj A. Optimization and development of antidiabetic phytosomes by the Box-Behnken design. J Liposome Res. 2018; 28(2): 161-172. DOI: https://doi.org/10.1080/08982104.2017.1311913

Matias D., Rijo P. and Reis C. Phytosomes as Biocompatible Carriers of Natural Drugs. Curr Med Chem. 2017; 24(6): 568-589.

Shoeibi A., Karimi E., Zareian M. and Oskoueian E. Enhancing Healthcare Outcomes and Modulating Apoptosis- and Antioxidant-Related Genes through the Nano-Phytosomal Delivery of Phenolics Extracted from Allium ampeloprasum. Genes (Basel). 2023; 14(8): 1547. DOI: https://doi.org/10.3390/genes14081547

Das A., Adhikari S., Deka D., et al. An Updated Review on the Role of Nanoformulated Phytochemicals in Colorectal Cancer. Medicina (Kaunas). 2023; 59(4): 685. DOI: https://doi.org/10.3390/medicina59040685

Zhang J., Tang Q., Xu X. and Li N. Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery. Int J Pharm. 2013; 448(1): 168-174. DOI: https://doi.org/10.1016/j.ijpharm.2013.03.021

Janjua K., Shehzad A., Shahzad R., Islam S. and Islam M. Nanocurcumin: A Double-Edged Sword for Microcancers. Curr Pharm Des. 2020; 26(45): 5783-5792. DOI: https://doi.org/10.2174/1381612826666201118100045

Goktas Z., Zu Y., Abbasi M., et al. Recent Advances in Nanoencapsulation of Phytochemicals to Combat Obesity and Its Comorbidities. J Agric Food Chem. 2020; 68(31): 8119-8131. DOI: https://doi.org/10.1021/acs.jafc.0c00131

Jamwal R. Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers [published correction appears in J Integr Med. 2019 Jul; 17(4): 310. J Integr Med. 2018; 16(6): 367-374. DOI: https://doi.org/10.1016/j.joim.2019.05.002

Dewanjee S., Chakraborty P., Mukherjee B. and De Feo V. Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy. Int J Mol Sci. 2020; 21(6): 2217. DOI: https://doi.org/10.3390/ijms21062217

Singh V., Arora D., Ansari M. and Sharma P. Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications. Phytother Res. 2019; 33(12): 3064-3089. DOI: https://doi.org/10.1002/ptr.6508

Kim M., Kim S. and Yang WM. Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease. Planta Med. 2014; 80(15): 1249-1258. DOI: https://doi.org/10.1055/s-0034-1383038

Ahmad S. and Hafeez A. Formulation and Development of Curcumin-Piperine-Loaded S-SNEDDS for the Treatment of Alzheimer's Disease. Mol Neurobiol. 2023; 60(2): 1067-1082. DOI: https://doi.org/10.1007/s12035-022-03089-7

Mahjoob M. and Stochaj U. Curcumin nanoformulations to combat aging-related diseases. Ageing Res Rev. 2021; 69: 101364. DOI: https://doi.org/10.1016/j.arr.2021.101364

Nguyen M., Yu H., Kiew T. and Hadinoto K. Cost-effective alternative to nano-encapsulation: Amorphous curcumin-chitosan nanoparticle complex exhibiting high payload and supersaturation generation. Eur J Pharm Biopharm. 2015; 96: 1-10. DOI: https://doi.org/10.1016/j.ejpb.2015.07.007

Baradaran S., Hajizadeh A., Khanjani S. and Moradi-Kor N. Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses. J Inflamm Res. 2020; 13: 45-51. DOI: https://doi.org/10.2147/JIR.S232462

Nandhini S., and Ilango K. Development and characterization of a nano-drug delivery system containing vasaka phospholipid complex to improve bioavailability using quality by design approach. Res Pharm Sci. 2020; 16(1): 103-117. DOI: https://doi.org/10.4103/1735-5362.305193

Mahmood T., Al-Samydai A., Sulaibi M., et al. Development of Pegylated Nano-Phytosome Formulation with Oleuropein and Rutin to Compare Anti-Colonic Cancer Activity with Olea Europaea Leaves Extract. Chem Biodivers. 2023; 20(8): e202300534. DOI: https://doi.org/10.1002/cbdv.202300534

Prabha J., Kumar M., Kumar D., Chopra S. and Bhatia A. Nano-platform Strategies of Herbal Components for the management of Rheumatoid Arthritis: A Review on the Battle for Next-Generation Formulations. Curr Drug Deliv.

Chen C., Wang J., Sun M., Li J. and Wang H. Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery. Biomed Pharmacother. 2022; 145: 112416. DOI: https://doi.org/10.1016/j.biopha.2021.112416

Attar E., Chaudhari V., Deokar C., Dyawanapelly S. and Devarajan P. Nano Drug Delivery Strategies for an Oral Bioenhanced Quercetin Formulation. Eur J Drug Metab Pharmacokinet. 2023; 48(5): 495-514. DOI: https://doi.org/10.1007/s13318-023-00843-7

Yu Z., Liu X., Chen H. and Zhu L. Naringenin-Loaded Dipalmitoylphosphatidylcholine Phytosome Dry Powders for Inhaled Treatment of Acute Lung Injury. J Aerosol Med Pulm Drug Deliv. 2020; 33(4): 194-204. DOI: https://doi.org/10.1089/jamp.2019.1569

Nashaat D., Elsabahy M., Hassanein K., El-Gindy G. and Ibrahim E.H. Development and in vivo evaluation of therapeutic phytosomes for alleviation of rheumatoid arthritis. Int J Pharm. 2023; 644: 123-332. DOI: https://doi.org/10.1016/j.ijpharm.2023.123332

Tafish A., El-Sherbiny M., Al-Karmalawy A., Soliman O. and Saleh N. Carvacrol-Loaded Phytosomes for Enhanced Wound Healing: Molecular Docking, Formulation, DoE-Aided Optimization, and in vitro/in vivo Evaluation. Int J Nanomedicine. 2023; 18: 5749-5780. DOI: https://doi.org/10.2147/IJN.S421617

Salman U.l., Ahmed M.B., Mazhar U.l., Shehzad A. and Lee Y. Switching from Conventional to Nano-natural Phytochemicals to Prevent and Treat Cancers: Special Emphasis on Resveratrol. Curr Pharm Des. 2019; 25(34): 3620-3632. DOI: https://doi.org/10.2174/1381612825666191009161018

Yadav N., Mudgal D., Anand R., Jindal S. and Mishra V. Recent development in nanoencapsulation and delivery of natural bioactives through chitosan scaffolds for various biological applications. Int J Biol Macromol. 2022; 220: 537-572. DOI: https://doi.org/10.1016/j.ijbiomac.2022.08.098

Behuria H., Biswal B. and Sahu S. Electroformation of liposomes and phytosomes using copper electrode. J Liposome Res. 2021; 31(3): 255-266. DOI: https://doi.org/10.1080/08982104.2020.1800729

Smeriglio A., Denaro M. and Trombetta D. Dietary Phytochemicals and Endrocrine-related Activities: An Update. Mini Rev Med Chem. 2018; 18(16): 1382-1397. DOI: https://doi.org/10.2174/1389557517666170711152406

Suvarna V., Bore B., Bhawar C. and Mallya R. Complexation of phytochemicals with cyclodextrins and their derivatives- an update. Biomed Pharmacother. 2022; 149: 112862. DOI: https://doi.org/10.1016/j.biopha.2022.112862

Tiwari R., Tiwari G., Sharma S. amd Ramachandran V. An Exploration of Herbal Extracts Loaded Phyto-phospholipid Complexes (Phytosomes) Against Polycystic Ovarian Syndrome: Formulation Considerations. Pharm Nanotechnol. 2023; 11(1): 44-55.

Kim S. and Imm J. The Effect of Chrysin-Loaded Phytosomes on Insulin Resistance and Blood Sugar Control in Type 2 Diabetic db/db Mice. Molecules. 2020; 25(23): 5503. DOI: https://doi.org/10.3390/molecules25235503

Alshahrani S. Optimization and Characterization of Cuscuta reflexa Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability. J Oleo Sci. 2022; 71(5): 671-683. DOI: https://doi.org/10.5650/jos.ess21318

Upaganlawar A., Polshettiwar S., Raut S., Tagalpallewar A. and Pande V. Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations. Curr Drug Metab. 2022; 23(11): 869-881. DOI: https://doi.org/10.2174/1389200223666220905162245

Babazadeh A., Zeinali M. and Hamishehkar H. Nano-Phytosome: A Developing Platform for Herbal Anti-Cancer Agents in Cancer Therapy. Curr Drug Targets. 2018; 19(2): 170-180. DOI: https://doi.org/10.2174/1389450118666170508095250

Cao X., Fu M., Wang L., et al. Oral bioavailability of silymarin formulated as a novel 3-day delivery system based on porous silica nanoparticles. Acta Biomater. 2012; 8(6): 2104-2112. DOI: https://doi.org/10.1016/j.actbio.2012.02.011

Ahmad S., Khan J., Kausar T., et al. Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix Tablets for Enhanced Oral Bioavailability. Molecules. 2023; 28(6): 2606. DOI: https://doi.org/10.3390/molecules28062606

Wang S., Su R., Nie S., et al. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J Nutr Biochem. 2014; 25(4): 363-376. DOI: https://doi.org/10.1016/j.jnutbio.2013.10.002

D'Arcy M.S. A review of the chemopreventative and chemotherapeutic properties of the phytochemicals berberine, resveratrol and curcumin, and their influence on cell death via the pathways of apoptosis and autophagy. Cell Biol Int. 2020; 44(9): 1781-1791. DOI: https://doi.org/10.1002/cbin.11402

Gupta M., Sansare V., Shrivastava B., Jadhav S. and Gurav P. Comprehensive review on use of phospholipid-based vesicles for phytoactive delivery. J Liposome Res. 2022; 32(3): 211-223. DOI: https://doi.org/10.1080/08982104.2021.1968430

Zhang Z., Li X, Sang S., et al. A review of nanostructured delivery systems for the encapsulation, protection, and delivery of silymarin: An emerging nutraceutical. Food Res Int. 2022; 156: 111314. DOI: https://doi.org/10.1016/j.foodres.2022.111314

Casula E., Letizia Manca M. and Manconi M. An integrative review on the uses of plant-derived bioactives formulated in conventional and innovative dosage forms for the local treatment of damaged nasal cavity. Int J Pharm. 2021; 610: 121-229. DOI: https://doi.org/10.1016/j.ijpharm.2021.121229

Taghipour Y., Hajialyani M., Naseri R., et al. Nanoformulations of natural products for management of metabolic syndrome. Int J Nanomedicine. 2019; 14: 5303-5321. DOI: https://doi.org/10.2147/IJN.S213831

Sabzichi M., Hamishehkar H., Ramezani F., et al. Luteolin-loaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling. Asian Pac J Cancer Prev. 2014; 15(13): 5311-5316. DOI: https://doi.org/10.7314/APJCP.2014.15.13.5311

Deleanu M., Toma L., Sanda G., et al. Formulation of Phytosomes with Extracts of Ginger Rhizomes and Rosehips with Improved Bioavailability, Antioxidant and Anti-Inflammatory Effects In Vivo. Pharmaceutics. 2023; 15(4): 1066. DOI: https://doi.org/10.3390/pharmaceutics15041066

Nagpal N., Arora M., Swami G., Rageeb and Kapoor R. Designing of a phytosome dosage form with Tecomella undulata as a novel drug delivery for better utilization. Pak J Pharm Sci. 2016; 29(4): 1231-1235.

Hou Z., Li Y., uang Y., et al. Phytosomes loaded with mitomycin C-soybean phosphatidylcholine complex developed for drug delivery. Mol Pharm. 2013; 10(1): 90-101. DOI: https://doi.org/10.1021/mp300489p

Ajazuddin. and Saraf S. Applications of novel drug delivery system for herbal formulations. Fitoterapia. 2010; 81(7): 680-689. DOI: https://doi.org/10.1016/j.fitote.2010.05.001

Kumar N., Goel R., Gaur P., et al. Development and evaluation of phytosome-loaded microsphere system for delivery of ginseng extract. J Microencapsul. 2021; 38(7-8): 496-506. DOI: https://doi.org/10.1080/02652048.2021.1982042

Sharma S. and Sahu A. Development, Characterization, and Evaluation of Hepatoprotective Effect of Abutilon indicum and Piper longum Phytosomes. Pharmacognosy Res. 2016; 8(1): 29-36. DOI: https://doi.org/10.4103/0974-8490.171102

Susilawati Y., Chaerunisa A. and Purwaningsih H. Phytosome drug delivery system for natural cosmeceutical compounds: Whitening agent and skin antioxidant agent. Journal of advanced pharmaceutical technology & research, 2021; 12(4): 327–334.

Cotellese R., Ledda A., Belcaro G., et al. Anthocran Phytosome: Prevention of Recurring Urinary Infections and Symptoms after Catheterization. J Diet Suppl. 2023; 20(1): 55-67. DOI: https://doi.org/10.1080/19390211.2021.1972074

Magrone T., Pugliese V., Fontana S. and Jirillo E. Human use of Leucoselect Phytosome with special reference to inflammatory-allergic pathologies in frail elderly patients. Curr Pharm Des. 2014; 20(6): 1011-1019. DOI: https://doi.org/10.2174/138161282006140220144411

Rondanelli M., Perna S., Gasparri C., et al. Promising Effects of 3-Month Period of Quercetin Phytosome Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study. Life (Basel). 2022; 12(1): 66. DOI: https://doi.org/10.3390/life12010066

Marcheggiani F., Orlando P., Silvestri S., et al. CoQ10 Phytosomes Improve Cellular Ubiquinone Uptake in Skeletal Muscle Cells: An Ex Vivo Study Using CoQ10-Enriched Low-Density Lipoproteins Obtained in a Randomized Crossover Study. Antioxidants (Basel). 2023; 12(4): 964. DOI: https://doi.org/10.3390/antiox12040964

Telange D., Patil A., Pethe A., Fegade H., Anand S. and Dave V. Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential. Eur J Pharm Sci. 2017; 108: 36-49. DOI: https://doi.org/10.1016/j.ejps.2016.12.009

Pastorelli D., Fabricio ASC., Giovanis P., et al. Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial. Pharmacol Res. 2018; 132: 72-79. DOI: https://doi.org/10.1016/j.phrs.2018.03.013

Kidd P. Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Altern Med Rev. 2009; 14(3): 226-246.

Di Pierro F., Menghi A., Barreca A., Lucarelli M. and Calandrelli A. Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Altern Med Rev. 2009; 14(2): 154-160.

Albalawi R., Binmahfouz L., Hareeri R., Shaik R. and Bagher A.M. Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis. Molecules. 2023; 28(6): 2741. DOI: https://doi.org/10.3390/molecules28062741

El-Menshawe S., Ali A., Rabeh M., Khalil N.M. Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product. Int J Nanomedicine. 2018; 13: 307-318. DOI: https://doi.org/10.2147/IJN.S153429

Direito R., Reis C., Roque L., et al. Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability. Pharmaceutics. 2019; 11(6): 296.

Matias D., Rijo P. and Reis CP. Phytosomes as Biocompatible Carriers of Natural Drugs. Curr Med Chem. 2017; 24(6): 568-589. DOI: https://doi.org/10.2174/0929867323666161028160855

Gnananath K., Sri Nataraj K. and Ganga Rao B. Phospholipid Complex Technique for Superior Bioavailability of Phytoconstituents. Adv Pharm Bull. 2017; 7(1): 35-42. DOI: https://doi.org/10.15171/apb.2017.005

Hendawy O., Al-Sanea M., Elbargisy R., et al. Development of Olive Oil Containing Phytosomal Nanocomplex for Improving Skin Delivery of Quercetin: Formulation Design Optimization, In Vitro and Ex Vivo Appraisals. Pharmaceutics. 2023; 15(4): 1124. DOI: https://doi.org/10.3390/pharmaceutics15041124

Yu F., Li Y., Chen Q., et al. Monodisperse microparticles loaded with the self-assembled berberine-phospholipid complex-based phytosomes for improving oral bioavailability and enhancing hypoglycemic efficiency. Eur J Pharm Biopharm. 2016; 103: 136-148. DOI: https://doi.org/10.1016/j.ejpb.2016.03.019

Zhang Z., Chen Y., Deng J., Jia X., Zhou J. and Lv H. Solid dispersion of berberine-phospholipid complex/TPGS 1000/SiO₂: preparation, characterization and in vivo studies. Int J Pharm. 2014; 465(1-2): 306-316. DOI: https://doi.org/10.1016/j.ijpharm.2014.01.023

Pooja D., Rupal J., G. S. C., et al. Phytosomes: A promising delivery system for anticancer agents by using phytochemicals in cancer therapy. Cell Mol Biol (Noisy-le-grand). 2023; 69(14): 1-8. DOI: https://doi.org/10.14715/cmb/2023.69.14.1

Dundar N. A., Ozdemir S., Uzuner K., et al. Characterization of pomegranate peel extract loaded nanophytosomes and the enhancement of bio-accessibility and storage stability. Food Chem. 2023; 398: 133921. DOI: https://doi.org/10.1016/j.foodchem.2022.133921

Soltanzadeh M., Peighambardoust S., Ghanbarzadeh B., Mohammadi M. and Lorenzo JM. Chitosan Nanoparticles as a Promising Nanomaterial for Encapsulation of Pomegranate (Punica granatum L.) Peel Extract as a Natural Source of Antioxidants. Nanomaterials (Basel). 2021; 11(6): 1439. DOI: https://doi.org/10.3390/nano11061439

Human C., Aucamp M., de Beer D., van der Rijst M. and Joubert E. Food-grade phytosome vesicles for nanoencapsulation of labile C-glucosylated xanthones and dihydrochalcones present in a plant extract matrix-Effect of process conditions and stability assessment. Food Sci Nutr. 2023; 11(12): 8093-8111. DOI: https://doi.org/10.1002/fsn3.3730

Tiwari R., Tiwari G., Sharma S. and Ramachandran V. An Exploration of Herbal Extracts Loaded Phyto-phospholipid Complexes (Phytosomes) Against Polycystic Ovarian Syndrome: Formulation Considerations. Pharm Nanotechnol. 2023; 11(1): 44-55. DOI: https://doi.org/10.2174/2211738510666220919125434

Ortega-Pérez L., Ayala-Ruiz L., Magaña-Rodríguez O., et al. Development and Evaluation of Phytosomes Containing Callistemon citrinus Leaf Extract: A Preclinical Approach for the Treatment of Obesity in a Rodent Model. Pharmaceutics. 2023; 15(9): 2178. DOI: https://doi.org/10.3390/pharmaceutics15092178

Direito R., Reis C., Roque L., et al. Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability. Pharmaceutics. 2019; 11(6): 296. DOI: https://doi.org/10.3390/pharmaceutics11060296

Abdelkader H., Longman M., Alany R. and Pierscionek B. Phytosome-hyaluronic acid systems for ocular delivery of L-carnosine. Int J Nanomedicine. 2016; 11: 2815-2827. DOI: https://doi.org/10.2147/IJN.S104774

Jain P., Taleuzzaman M., Kala C., Kumar Gupta D., Ali A. and Aslam M. Quality by design (Qbd) assisted development of phytosomal gel of aloe vera extract for topical delivery. J Liposome Res.

Mi P. Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics. Theranostics. 2020; 10(10): 4557-4588. DOI: https://doi.org/10.7150/thno.38069

Singh D., Rawat M., Semalty A. and Semalty M. Rutin-phospholipid complex: an innovative technique in novel drug delivery system- NDDS. Curr Drug Deliv. 2012; 9(3): 305-314. DOI: https://doi.org/10.2174/156720112800389070

Wang H., Cui Y., Fu Q., et al. A phospholipid complex to improve the oral bioavailability of flavonoids. Drug Dev Ind Pharm. 2015; 41(10): 1693-1703. DOI: https://doi.org/10.3109/03639045.2014.991402

Sri K., Kondaiah A., Ratna J. and Annapurna A. Preparation and characterization of quercetin and rutin cyclodextrin inclusion complexes. Drug Dev Ind Pharm. 2007; 33(3): 245-253. DOI: https://doi.org/10.1080/03639040601150195

Saoji S., Raut N., Dhore P., Borkar C., Popielarczyk M. and Dave VS. Preparation and Evaluation of Phospholipid-Based Complex of Standardized Centella Extract (SCE) for the Enhanced Delivery of Phytoconstituents. AAPS J. 2016; 18(1): 102-114. DOI: https://doi.org/10.1208/s12248-015-9837-2

Telange D., Nirgulkar S., Umekar M., Patil A., Pethe A. and Bali N. Enhanced transdermal permeation and anti-inflammatory potential of phospholipids complex-loaded matrix film of umbelliferone: Formulation development, physico-chemical and functional characterization. Eur J Pharm Sci. 2019; 131: 23-38. DOI: https://doi.org/10.1016/j.ejps.2019.02.006

Freag M., Elnaggar Y. and Abdallah O. Lyophilized phytosomal nanocarriers as platforms for enhanced diosmin delivery: optimization and ex vivo permeation. Int J Nanomedicine. 2013; 8: 2385-2397. DOI: https://doi.org/10.2147/IJN.S45231

Hanif H., Abdollahi V., Javani Jouni F., et al. Quercetin nano phytosome: as a novel anti-leishmania and anti-malarial natural product. J Parasit Dis. 2023; 47(2): 257-264. DOI: https://doi.org/10.1007/s12639-022-01561-8

Maramaldi G., Togni S., Pagin I., et al. Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study. Clin Cosmet Investig Dermatol. 2016; 9: 55-62. DOI: https://doi.org/10.2147/CCID.S98890

Susilawati Y., Chaerunisa A., Purwaningsih H. Phytosome drug delivery system for natural cosmeceutical compounds: Whitening agent and skin antioxidant agent. J Adv Pharm Technol Res. 2021;12(4): 327-334. DOI: https://doi.org/10.4103/japtr.JAPTR_100_20

Amit P., Tanwar Y., Rakesh S., Poojan P. Phytosome: Phytolipid drug delivery system for improving bioavailability of herbal drug. J Pharm Sci Biosci Res. 2013; 3: 51-7.

Patel J., Patel R., Khambholja K. and Patel N. An overview of phytosomes as an advanced herbal drug delivery system. Asian J Pharm Sci. 2009; 4: 363-71.

Aggarwal K. and Gupta A. and Chaturvedi S. Improvement in bioavailability of class III drug: Phytolipid delivery system. Int J Pharm Pharm Sci. 2012; 4(1): 38.

Mazumder A., Dwivedi A., du Preez J. and du Plessis J. In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex. Int J Pharm. 2016; 498(1-2): 284. DOI: https://doi.org/10.1016/j.ijpharm.2015.12.027

Alholy T. and Khaddam, W. Extracellular Synthesis of Magnesium Oxide at Nano and Bulk Scale: Antifungal Effect Against Candida albicans, Aspergillus niger: Anti-fungal effect of MgO nano and bulk particles. Jordan Journal of Pharmaceutical Sciences. 2023; 16(4): 740–752.

Keerthi B., Pingali S. and Srinivas P. Formulation and evaluation of capsule of Ashwagandha phytosome. Int J Pharm Sci Rev Res. 2014; 29(2): 140.

Dhase S. and Saboo S. Preparation and evaluation of phytosome containing methanolic extract of leaves of Aegle marmelos (Bael). Int J Pharm Technol Res. 2015; 8(6): 232-3.

Surendra T., Dilip K., Lipika B. and Suresh K. A review on phytosomes, their characterization, advancement and potential for transdermal application. J Drug Deliv Ther. 2013; 3: 147-52. DOI: https://doi.org/10.22270/jddt.v3i3.508

Mishra B. Phytosomes: A promising system of herbal drug delivery. J. Chem. Pharm. Res. 2013; 2(4): 309-315.

Sikarwar M. A Review on Phytosome Technology as a Novel Approach to Improve the Bioavailability of Nutraceuticals. Int J of Adv & tech, Planta Ind. 2005; 1(2): 1-3.

Deshpande p., Pathak A. and Gothalwal R. Phytosomes: A promising system of herbal drug delivery. J. New Bio. Rep. 2014; 3(3): 212 – 220.

Bhattacharjee A. Phytosomes: A promising system of herbal drug delivery. Int. J. Inno. Pharm. Sci. Res. 2015; 3(6): 730-739.

Singha A., Saharanb V., Singha M. and Bhandaria A. Phytosome: Drug Delivery System for Polyphenolic Phytoconstituents. Iran. J. Pharm. Sci. 2011; 7(4): 209-219.

Rajendhiran N. and Bhattacharyya S. Preparation and Evaluation of Nanolipid Carriers of Bedaquiline- In vitro Evaluation and in silico Prediction. Jordan Journal of Pharmaceutical Sciences. 2024; 17(3): 450–467 DOI: https://doi.org/10.35516/jjps.v17i3.1970