دراسة النشاط المضاد للسرطان لمستخلص لحاء نبات لانييا كورومانديليكا الإيثانولي في سرطان الفئران البيضاء السويسرية المُستحث بواسطة 7،12-ثنائي ميثيل بنز (أ) أنثراسين
DOI:
https://doi.org/10.35516/jjps.v19i1.2772الكلمات المفتاحية:
Anticancer، histopathology، 5FU، Lannea coromandelica، MDA، SODالملخص
هدفت هذه الدراسة إلى تقييم الخصائص المضادة للسرطان لمستخلص لحاء نبات لانييا كورومانديليكا (LC) باستخدام نموذج التسرطن ثنائي المراحل، وذلك عن طريق تحفيز السرطان في فئران سويسرية بيضاء لمدة 16 أسبوعًا باستخدام 7،12-ثنائي ميثيل بنز (أ) أنثراسين (DMBA) وزيت الكروتون. تم تطبيق مستخلص لحاء LC وكريم فلونيدا 5% من 5-فلورويوراسيل (5-FU) كدواء معياري موضعيًا يوميًا لمدة 16 أسبوعًا بعد تطبيق DMBA. أدى العلاج الموضعي بالمستخلص إلى انخفاض ملحوظ في العديد من مؤشرات الورم. أظهر تأثير المستخلص على مستوى إنزيمات ديسموتاز الفائق (SOD) والكاتالاز (CAT) نتائج معنوية (p<0.05*) مقارنةً بالمجموعة المعيارية. كان مستوى مالونديالدهيد (MDA) في المستخلص مماثلاً تقريبًا لمستوى المجموعة المعيارية، بل إن قيم هذه المجموعات كانت أقل من قيمة المجموعة الطبيعية. ارتفع نشاط الجلوتاثيون المختزل (GSH) في المجموعة المعالجة بالمستخلص مقارنةً بمجموعة التحكم المعالجة بالمادة المسرطنة. ولوحظت تغيرات نسيجية مرضية في مجموعة التحكم المعالجة بالمادة المسرطنة، تمثلت في فرط التنسج، وخلل التقرن، وسرطان الخلايا الحرشفية جيد التمايز، ووجود لآلئ متقرنة، بينما انخفضت هذه التغيرات بعد إعطاء المستخلص والدواء القياسي. وتُشير النتائج الإجمالية إلى أن مستخلص لحاء نبات LC يتمتع بنشاط قوي مضاد للسرطان، مما يُوفر أساسًا علميًا لخصائصه الوقائية الكيميائية.
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##plugins.generic.dates.accepted## 2025-01-16
##plugins.generic.dates.published## 2026-01-12







