التطبيق المفيد للسبيرولينا في التخفيف من اضطرابات الملامح الدهنية والتغيرات السكرية الناتجة عن نظام غذائي عالي السعرات الحرارية لدى جرذان ويستار
DOI:
https://doi.org/10.35516/jjps.v19i1.3449الكلمات المفتاحية:
السبيرولينا، النظام الغذائي، جرذ ويستار، زيادة الوزن، الاختلال الأيضيالملخص
إن النظام الغذائي غير المتوازن يؤدي حتمًا إلى زيادة الوزن وحدوث اختلالات أيضية. ويمكن أن تكون السبيرولينا (Arthrospira platensis) مكملًا مفيدًا لمعالجة هذه الحالة. يهدف هذا العمل إلى دراسة تأثير إضافة السبيرولينا بنسبة 2% في غذاء جرذان ويستار غير المتوازن على الوزن وبعض المعايير البيوكيميائية المرتبطة بالأيض. تم إحداث التغيرات لدى جرذان ويستار عبر إدخال مطوّل لنظام غذائي عالي السعرات الحرارية. وتلقت الحيوانات الأنظمة الغذائية التجريبية التالية: نظام غذائي قياسي (S)، نظام غذائي عالي السعرات الحرارية (H)، ونظام غذائي مُدعّم بالسبيرولينا (SP). أُتيح للجرذان الوصول الحر (ad libitum) إلى حصتها اليومية البالغة 15 غرامًا، والتي قُدمت كل صباح. تم قياس وزن الجرذان والمعايير المصلية (سكر الدم، الكوليسترول، والدهون الثلاثية) ومقارنتها تبعًا للأنظمة الغذائية الثلاثة المطبقة. أظهرت القياسات المنجزة أن وزن الجرذان ازداد بشكل ملحوظ (20.95 غ) تحت النظام الغذائي H مقارنةً بالنظام S. وقد سمح النظام SP بالعودة إلى تغير وزني طبيعي (19.25 غ) بعد 67 يومًا. كما أن سكر الدم، والكوليسترول الكلي، والدهون الثلاثية، وكوليسترول البروتينات الدهنية منخفضة الكثافة LDL-C، التي ارتفعت بشكل كبير جدًا في النظام H (0.53 غ/ل، 0.25 غ/ل، 0.2 غ/ل على التوالي)، قد انخفضت في النظام SP لتصبح على نفس مستوى القيم المسجلة في النظام S (0.35 غ/ل، 0.62 غ/ل، 0.46 غ/ل على التوالي). في المقابل، كان معدل كوليسترول البروتينات الدهنية عالية الكثافة HDL-C أقل تأثرًا بتغير النظام الغذائي. جميع النتائج المتحصل عليها تصب في صالح وجود تأثير مفيد للسبيرولينا على المجال الأيضي لدى جرذان ويستار، مما يبرز أهمية إدماجها في النظام الغذائي للإنسان.
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